Results 51 to 60 of about 3,366,415 (310)

Heritability of quantitative autism spectrum traits in adults: A family‐based study

Autism Research, 2021
AbstractAutism spectrum disorder (ASD) comprises a multi‐dimensional set of quantitative behavioral traits expressed along a continuum in autistic and neurotypical individuals. ASD diagnosis—a dichotomous trait—is known to be highly heritable and has been used as the phenotype for most ASD genetic studies.
Sara C. Taylor, Samantha Steeman, Brielle N. Gehringer, Holly C. Dow, Allison Langer, Eric Rawot, Leat Perez, Matthew Goodman, Zoe Smernoff, Mahip Grewal, Oceania Eshraghi, Ashley A. Pallathra, Catherine Oksas, Melissa Mendez, Ruben C. Gur, Daniel J. Rader, Maja Bucan, Laura Almasy, Edward S. Brodkin   +18 more
openaire   +3 more sources

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models [PDF]

, 2011
Objective: Genome-wide association studies have identified robust associations between single nucleotide polymorphisms and complex traits. As the proportion of phenotypic variance explained is still limited for most of the traits, larger and larger meta ...
Puetter, Carolin, Wichmann, Heinz-Erich, Scherag, Andre, Nöthen, M.M., Wichmann, H.-E., Carolin Pütter, Sonali Pechlivanis, Karl-Heinz Jöckel, Pechlivanis, S., André Scherag, Joeckel, Karl-Heinz, Scherag, A., Heinz-Erich Wichmann, Pütter, C., Pechlivanis, Sonali, Noethen, Markus M., Jöckel, K.-H., Markus M. Nöthen   +17 more
core   +1 more source

A Latent Variable Approach to Multivariate Quantitative Trait Loci [PDF]

, 2010
A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and ...
Päivi Komulainen, Outi Savolainen, Mikko J. Sillanpää, Bob O'Hara   +3 more
core  

The Heritability of Mating Behaviour in a Fly and Its Plasticity in Response to the Threat of Sperm Competition [PDF]

, 2014
Phenotypic plasticity is a key mechanism by which animals can cope with rapidly changeable environments, but the evolutionary lability of such plasticity remains unclear.
Price, TA, Bretman, Amanda J., Tom A R Price, Price, Tom A. R., Walling, CA, Anne Lizé, Lizé Anne, Bretman, A, Lizé, A, Bretman Amanda, Amanda Bretman, Bretman, Amanda, Craig A Walling, Price Tom A. R., Lize, Anne, Walling, Craig A., Walling Craig A., University of Liverpool, University of Leeds, School of Biological Sciences   +19 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A stable and major QTL region on chromosome 2 conditions pod shape in cultivated peanut (Arachis hyopgaea L.)

Journal of Integrative Agriculture, 2023
Peanut pod shape is a heritable trait which affects the market acceptance of in-shell peanut products. In order to determine the genetic control of pod shape, six component traits of pod shape (pod length, pod width, pod length/width ratio, pod roundness,
Sheng-zhong ZHANG, Xiao-hui HU, Fei-fei WANG, Ye CHU, Wei-qiang YANG, Sheng XU, Song WANG, Lan-rong WU, Hao-liang YU, Hua-rong MIAO, Chun FU, Jing CHEN   +11 more
doaj   +1 more source

Efficient QTL detection for nonhost resistance in wild lettuce: backcross inbred lines versus F2 [PDF]

, 2008
In plants, several population types [F2, recombinant inbred lines, backcross inbred lines (BILs), etc.] are used for quantitative trait locus (QTL) analyses.
Stam, P., M. J. W. Jeuken, P. Stam, Pelgrom, K.T.B., K. Pelgrom, Jeuken, M.J.W., Lindhout, P., P. Lindhout   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome

Frontiers in Genetics, 2019
While over ten thousand genetic loci have been associated with phenotypic traits and inherited diseases in genome-wide association studies, in most cases only a relatively small proportion of the trait heritability is explained and biological mechanisms ...
Gabriella Farries, Kenneth Bryan, Charlotte L. McGivney, Paul A. McGettigan, Katie F. Gough, John A. Browne, David E. MacHugh, David E. MacHugh, Lisa Michelle Katz, Emmeline W. Hill, Emmeline W. Hill   +10 more
doaj   +1 more source

Female barn owls (Tyto alba) advertise good genes [PDF]

, 2000
The good genes hypothesis of sexual selection postulates that ornamentation signals superior genetic quality to potential mates. Support for this hypothesis comes from studies on male ornamentation only, while it remains to be shown that female ...
Jungi, T. W., Pfister, H, Roulin, Alexandre,, Dijkstra, Cor,, Pfister, Hedi,, Roulin, A, Jungi, T.W, Dijkstra, C., Jungi, Thomas W.,   +8 more
core   +2 more sources