Results 31 to 40 of about 3,366,415 (310)

Understanding Disease Susceptibility through Population Genomics [PDF]

Genomics & Informatics, 2012
Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are ...
Seonggyun Han, Junnam Lee, Sangsoo Kim
doaj   +1 more source

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
Alokail Majed S, Shaun B Sabico, Assim A Alfadda, Sabico, Shaun, George P Chrousos, Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Philip McTernan, Al-Daghri, Nasser M., Greg C Gibson, Al-Attas Omar S, Majed S Alokail, Gibson, Greg, Alkharfy Khalid M, Alfadda, Assim, Chrousos, George P., Gibson Greg C, Chrousos George P, McTernan Philip, Nasser M Al-Daghri, Sabico Shaun B, Al-Daghri Nasser M, Alfadda Assim A, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy   +26 more
core   +2 more sources

Developmental and genetic effects on behavioral and life‐history traits in a field cricket

Ecology and Evolution, 2019
A fundamental goal of evolutionary ecology is to identify the sources underlying trait variation on which selection can act. Phenotypic variation will be determined by both genetic and environmental factors, and adaptive phenotypic plasticity is expected
Tina W. Wey, Denis Réale, Clint D. Kelly   +2 more
doaj   +1 more source

An Effective Method to Identify Heritable Components from Multivariate Phenotypes.

PLoS ONE, 2015
Multivariate phenotypes may be characterized collectively by a variety of low level traits, such as in the diagnosis of a disease that relies on multiple disease indicators. Such multivariate phenotypes are often used in genetic association studies.
Jiangwen Sun, Henry R Kranzler, Jinbo Bi
doaj   +1 more source

A Bayesian approach to detect QTL affecting a simulated binary and quatitative trait [PDF]

, 2011
Background - We analyzed simulated data from the 14th QTL-MAS workshop using a Bayesian approach implemented in the program iBay. The data contained individuals genotypes for 10,031 SNPs and phenotyped for a quantitative and a binary trait. Results - For
Janss, L.L.G., Heuven, H.C.M., Geneeskunde van gezelschapsdieren, Advances in Veterinary Medicine, Bouwman, A.C., Aniek C Bouwman, Henri CM Heuven, Luc LG Janss   +7 more
core   +2 more sources

Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross [PDF]

, 2007
An F-2 broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits.
Sharman, P. W. A., Morrice, D. R., Law, A. S., Hocking, P. M., Burt, D. W.   +4 more
core   +1 more source

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment

npj Precision Oncology, 2023
To individualise breast cancer (BC) prevention, markers to follow a person’s changing environment and health extending beyond static genetic risk scores are required.
Chiara Herzog, Allison Jones, Iona Evans, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan, Martin Widschwendter   +10 more
doaj   +1 more source

A major QTL controls susceptibility to spinal curvature in the curveback guppy

BMC Genetics, 2011
Background Understanding the genetic basis of heritable spinal curvature would benefit medicine and aquaculture. Heritable spinal curvature among otherwise healthy children (i.e.
Dreyer Christine, Weigel Detlef, Ahmadi Roozbeh, Parent Jennifer, Christians Julian K, Gorman Kristen F, Breden Felix   +6 more
doaj   +1 more source

Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]

, 2014
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M, Ellis, Philip A., Pemberton, Josephine M., Bérénos, Camillo, Ellis, Philip A, Pilkington, Jill G., Pilkington, Jill G   +6 more
core   +1 more source

On Flexible finite polygenic models for multiple-trait evaluation [PDF]

, 2002
Finite polygenic models (FPM) might be an alternative to the infinitesimal model (TIM) for the genetic evaluation of pedigreed multiple-generation populations for multiple quantitative traits.
Bink, M.C.A.M.
core   +1 more source