Results 11 to 20 of about 55,223 (296)

Heritability and tissue specificity of expression quantitative trait loci. [PDF]

PLoS Genetics, 2006
Variation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling and linkage analysis to the regulation of gene
Enrico Petretto, Jonathan Mangion, Nicholas J Dickens, Stuart A Cook, Mande K Kumaran, Han Lu, Judith Fischer, Henrike Maatz, Vladimir Kren, Michal Pravenec, Norbert Hubner, Timothy J Aitman   +11 more
doaj   +5 more sources

Niche construction in quantitative traits: heritability and response to selection

Proceedings of the Royal Society B: Biological Sciences, 2022
A central tenet of niche construction (NC) theory is that organisms can alter their environments in heritable and evolutionarily important ways, often altering selection pressures. We suggest that the physical changes niche constructors make to their environments may also alter trait heritability and the response of phenotypes to selection. This effect
Laurel Fogarty, Michael J. Wade
openaire   +4 more sources

Broad and Narrow Heritabilities of Quantitative Traits in a Founder Population [PDF]

The American Journal of Human Genetics, 2001
Estimation of the components of variance for a quantitative trait allows one to evaluate both the degree to which genetics influences the trait and the trait's underlying genetic architecture. For particular traits, the estimates also may have implications for discriminating between potential models of selection and for choosing an appropriate model ...
Abney, Mark, McPeek, Mary Sara, Ober, Carole   +2 more
openaire   +2 more sources

The role of heritability in mapping expression quantitative trait loci [PDF]

BMC Proceedings, 2007
Abstract Gene expression, as a heritable complex trait, has recently been used in many genome-wide linkage studies. The estimated overall heritability of each trait may be considered as evidence of a genetic contribution to the total phenotypic variation, which implies the possibility of mapping genome regions responsible for the gene ...
Huang, Song, Ballard, David, Zhao, Hongyu   +2 more
openaire   +2 more sources

Heritability Estimates of Some Quantitative Traits in Potatoes

Turkish Journal Of Field Crops, 2014
Broad-sense heritability (H) values of some quantitative traits in a potato population comprising 21 genotypes grown at Bornova, Izmir, Turkey during the 2013 and 2014 growing seasons were estimated by using the variance components analysis method. Based on the combined analysis of variance performed over two years, the following moderate to high level
OZTURK, Gulsum, YILDIRIM, Zihin
openaire   +5 more sources

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1 [PDF]

Scientific Reports, 2020
AbstractImpulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unbiased, genome-wide approach to identify genetic markers associated with impulsivity in ...
Jupp, Bianca, Pitzoi, Silvia, Petretto, Enrico, Mar, Adam C, Oliver, Yolanda Pena, Jordan, Emily R, Taylor, Stephanie, Atanur, Santosh S, Srivastava, Prashant K, Saar, Kathrin, Hubner, Norbert, Sommer, Wolfgang H, Staehlin, Oliver, Spanagel, Rainer, Robinson, Emma S, Schumann, Gunter, Moreno, Margarita, Everitt, Barry J, Robbins, Trevor W, Aitman, Timothy J, Dalley, Jeffrey W   +20 more
openaire   +6 more sources

A population genetic interpretation of GWAS findings for human quantitative traits. [PDF]

PLoS Biology, 2018
Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait.
Yuval B Simons, Kevin Bullaughey, Richard R Hudson, Guy Sella   +3 more
doaj   +1 more source

Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci [PDF]

Biology Letters, 2011
Most natural populations display substantial genetic variation in behaviour, morphology, physiology, life history and the susceptibility to disease. A major challenge is to determine the contributions of individual loci to variation in complex traits.
Alison G, Scoville, Young Wha, Lee, John H, Willis, John K, Kelly   +3 more
openaire   +2 more sources

Genetically Distinct Behavioral Modules Underlie Natural Variation in Thermal Performance Curves

G3: Genes, Genomes, Genetics, 2019
Thermal reaction norms pervade organismal traits as stereotyped responses to temperature, a fundamental environmental input into sensory and physiological systems. Locomotory behavior represents an especially plastic read-out of animal response, with its
Gregory W. Stegeman, Scott E. Baird, William S. Ryu, Asher D. Cutter   +3 more
doaj   +1 more source

The lipoprotein subfraction profile: heritability and identification of quantitative trait loci [PDF]

Journal of Lipid Research, 2008
The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to identify gene loci influencing the lipoprotein ...
Bernhard Kaess, Marcus Fischer, Andrea Baessler, Klaus Stark, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Heribert Schunkert, Guenter Riegger, Christian Hengstenberg   +9 more
openaire   +3 more sources