Results 11 to 20 of about 22,558 (261)

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. [PDF]

PLoS Genetics, 2006
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different individuals have been mapped to the causal regulatory regions, termed expression quantitative trait loci.
Yang Li, Olga Alda Alvarez, Evert W Gutteling, Marcel Tijsterman, Jingyuan Fu, Joost A G Riksen, Esther Hazendonk, Pjotr Prins, Ronald H A Plasterk, Ritsert C Jansen, Rainer Breitling, Jan E Kammenga   +11 more
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Anterior chamber depth in mice is controlled by several quantitative trait loci.

PLoS ONE, 2023
Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability.
Demelza R Larson, Allysa J Kimber, Kacie J Meyer, Michael G Anderson   +3 more
doaj   +1 more source

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1 [PDF]

Scientific Reports, 2020
AbstractImpulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unbiased, genome-wide approach to identify genetic markers associated with impulsivity in ...
Jupp, Bianca, Pitzoi, Silvia, Petretto, Enrico, Mar, Adam C, Oliver, Yolanda Pena, Jordan, Emily R, Taylor, Stephanie, Atanur, Santosh S, Srivastava, Prashant K, Saar, Kathrin, Hubner, Norbert, Sommer, Wolfgang H, Staehlin, Oliver, Spanagel, Rainer, Robinson, Emma S, Schumann, Gunter, Moreno, Margarita, Everitt, Barry J, Robbins, Trevor W, Aitman, Timothy J, Dalley, Jeffrey W   +20 more
openaire   +6 more sources

A population genetic interpretation of GWAS findings for human quantitative traits. [PDF]

PLoS Biology, 2018
Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait.
Yuval B Simons, Kevin Bullaughey, Richard R Hudson, Guy Sella   +3 more
doaj   +1 more source

Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci [PDF]

Biology Letters, 2011
Most natural populations display substantial genetic variation in behaviour, morphology, physiology, life history and the susceptibility to disease. A major challenge is to determine the contributions of individual loci to variation in complex traits.
Alison G, Scoville, Young Wha, Lee, John H, Willis, John K, Kelly   +3 more
openaire   +2 more sources

Genetically Distinct Behavioral Modules Underlie Natural Variation in Thermal Performance Curves

G3: Genes, Genomes, Genetics, 2019
Thermal reaction norms pervade organismal traits as stereotyped responses to temperature, a fundamental environmental input into sensory and physiological systems. Locomotory behavior represents an especially plastic read-out of animal response, with its
Gregory W. Stegeman, Scott E. Baird, William S. Ryu, Asher D. Cutter   +3 more
doaj   +1 more source

The lipoprotein subfraction profile: heritability and identification of quantitative trait loci [PDF]

Journal of Lipid Research, 2008
The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to identify gene loci influencing the lipoprotein ...
Bernhard Kaess, Marcus Fischer, Andrea Baessler, Klaus Stark, Fritz Huber, Werner Kremer, Hans Robert Kalbitzer, Heribert Schunkert, Guenter Riegger, Christian Hengstenberg   +9 more
openaire   +3 more sources

Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study

BMC Genomics, 2008
Background Many studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait
Sun Wei, Yuan Shinsheng, Li Ker-Chau
doaj   +1 more source

Using social interaction models for genetic analysis of skin damage in gilts

Genetics Selection Evolution, 2023
Background Skin damage is a trait of economic and welfare importance that results from social interactions between animals. These interactions may produce wound signs on the gilt’s skin as a result of damage behavior (i.e., fighting), biting syndromes (i.
Natália Galoro Leite, Egbert Knol, Shogo Tsuruta, Stefanie Nuphaus, Roos Vogelzang, Daniela Lourenco   +5 more
doaj   +1 more source

The role of social effects in selection for animal improvement

Revista Brasileira de Zootecnia, 2008
Quantitative genetics can be used to understand how traits will respond to artificial selection regimes, and therefore, it can be an important tool in the development of selective breeding programs for animal improvement. In order to predict the response
Jason B. Wolf
doaj   +1 more source