Results 111 to 120 of about 313,777 (344)

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Rice root genetic architecture: Meta-analysis from a drought QTL database [PDF]

, 2009
During the last 10 years, a large number of quantitative trait loci (QTLs) controlling rice root morphological parameters have been detected in several mapping populations by teams interested in improving drought resistance in rice.
Ahmadi, Nourollah, Courtois, Brigitte, Frouin, Julien, Hamelin, Chantal, Khowaja, Farhkanda S., Price, Adam H., Rami, Jean-François, Ruiz, Manuel   +7 more
core   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Optimal selection on two quantitative trait loci with linkage

Genetics Selection Evolution, 2002
A mathematical approach to optimize selection on multiple quantitative trait loci (QTL) and an estimate of residual polygenic effects was applied to selection on two linked or unlinked additive QTL.
Moreau Laurence, Chakraborty Reena, Dekkers Jack CM   +2 more
doaj   +1 more source

forqs: Forward-in-time Simulation of Recombination, Quantitative Traits, and Selection [PDF]

, 2013
forqs is a forward-in-time simulation of recombination, quantitative traits, and selection. It was designed to investigate haplotype patterns resulting from scenarios where substantial evolutionary change has taken place in a small number of generations ...
Kessner, Darren, Novembre, John
core  

Quantitative trait loci conferring grain mineral nutrient concentrations in durum wheat 3 wild emmer wheat RIL population [PDF]

, 2009
Mineral nutrient malnutrition, and particularly deficiency in zinc and iron, afflicts over 3 billion people worldwide. Wild emmer wheat, Triticum turgidum ssp. dicoccoides, genepool harbors a rich allelic repertoire for mineral nutrients in the grain.
A Blanco, A Blanco, A Börner, A Distelfeld, A Distelfeld, A Mesfin, A Morgounov, A Yilmaz, Abraham B. Korol, AH Paterson, AJ Barneix, Atilla Yazici, B Feil, BM Waters, C Groos, C Hotz, C Löffler, C Uauy, CN Law, CV Peterson, D Vreugdenhil, DF Calderini, E Nevo, F-X Oury, G Ladizinsky, GA Churchill, GB Gregorio, H Marschner, HE Bouis, Hikmet Budak, I Cakmak, I Cakmak, I Cakmak, I Cakmak, IA Khan, Ismail Cakmak, J Dvořák, JA McVittie, JCR Stangoulis, JL Gonzalez-Hernandez, JN Pearson, JNA Lott, JW Snape, L Avivi, L Gauer, Levent Ozturk, LR Joppa, M Cox, M Feldman, M Feldman, M Prasad, MA Grusak, MR Perretant, N Grotz, PA Sanchez, R Garnett, R Scarth, R Shi, RJ Larsen, RM Welch, RM Welch, S Abbo, S Harjit, S Huang, S McCouch, S Salvi, S Zanetti, SD Tanksley, SH Guzmán-Maldonado, TP O’Brien, Tzion Fahima, V Raboy, V Raboy, W Dijkshoorn, W Zhang, Y Genc, Yan Jun, Yehoshua Saranga, YI Ronin, Z Peleg, Z Peleg, Zvi Peleg   +81 more
core   +1 more source

Phylogenomics, ecomorphological evolution, and historical biogeography in Deuterocohnia (Bromeliaceae: Pitcairnioideae)

American Journal of Botany, EarlyView.
Abstract Premise Species of Deuterocohnia (17 spp.) show extraordinary variation in elevation (0–3900 m a.s.l.) and growth forms, and many have narrow geographic distributions in the west‐central Andes and the Peru‐Chile coast. Previous research using few plastid and nuclear loci failed to produce well‐resolved or supported phylogenies.
Bing Li, Nicole Schütz, Kurt Weising, Georg Zizka, Jacob B. Landis, Thomas J. Givnish   +5 more
wiley   +1 more source

Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer.

PLoS Genetics, 2016
The interpretation of noncoding alterations in cancer genomes presents an unresolved problem in cancer studies. While the impact of somatic variations in protein-coding regions is widely accepted, noncoding aberrations are mostly considered as passenger ...
Holger Heyn
doaj   +1 more source

Behavior Decoding Delineates Seizure Microfeatures and Associated Sudden Death Risks in Mouse Models of Epilepsy

Annals of Neurology, EarlyView.
Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen, Jaden Thomas, Xianhui Chen, Jaden Zelidon, Mariam Najeeb, Abigayle Hahn, Ping Zhang, Aaron Sathyanesan, Bin Gu   +8 more
wiley   +1 more source

Dissection of the E8 locus in two early maturing Canadian soybean populations

Frontiers in Plant Science
Soybean [Glycine max (L.) Merr.] is a short-day crop for which breeders want to expand the cultivation range to more northern agro-environments by introgressing alleles involved in early reproductive traits.
Jérôme Gélinas Bélanger, Jérôme Gélinas Bélanger, Tanya Rose Copley, Valerio Hoyos-Villegas, Louise O’Donoughue   +4 more
doaj   +1 more source