Results 91 to 100 of about 3,758,767 (255)
Arthritis &Rheumatology, EarlyView.Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda +5 more
wiley +1 more source
Understanding out‐of‐field teacher self‐efficacy beliefs: A person‐centred approach
British Educational Research Journal, EarlyView.Abstract Teaching out‐of‐field (OOF) has been a widespread global phenomenon and a cause of concern for school leaders and policymakers due to the potential impact it has on teaching quality and student learning. However, research on how the nature of OOF teaching impacts various teachers' psychological attributes such as teacher self‐efficacy (TSE ...
Hoi Vo +5 more
wiley +1 more source
Functional Diversity and Oleaginous Potential of Fungal Strains From Hawaiian Soil Ecosystems
Biotechnology and Bioengineering, EarlyView.ABSTRACT Fungi represent an important but underexplored resource for microbial lipid production, including nutritionally valuable polyunsaturated fatty acids. Hawaiian soils, shaped by volcanic parent materials and strong environmental gradients, provide a unique setting for discovering functionally diverse fungal strains with distinct metabolic traits.
Yu Wang +12 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The glutamine synthetase expression system is widely used for therapeutic protein biomanufacturing in Chinese hamster ovary (CHO) cells. Here, we present the design of an enhanced glutamine synthetase vector for generating CHOK1SV GS‐KO stable pools that produce recombinant proteins at multigram‐per‐liter levels. We first developed a synthetic
Yusuf B. Johari +11 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT The transition to a circular economy (CE) increasingly depends on circular ecosystems: networks of autonomous yet interdependent actors that must coordinate material, information, and value flows to narrow, slow, and close resource loops. This creates a governance problem: Circularity requires orchestration, yet no single actor can impose ...
Felix Carl Schultz +3 more
wiley +1 more source
Mitigating Chatbot Service Failures: The Roles of Anthropomorphism, Acknowledgment, and Apology
Journal of Consumer Behaviour, EarlyView.ABSTRACT This study examines how chatbot anthropomorphism shapes consumer responses to service failure by distinguishing between process failure and outcome failure and by testing alternative recovery responses. Across three pretests (N = 30, 120 and 240) and two scenario‐based experiments (Study 1: N = 346; Study 2: N = 778), consumers evaluated ...
Juyon Lee, Wujin Chu, Rajat Roy
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples +10 more
wiley +1 more source
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.
, 2001 To investigate the genetic control of salt-induced hypertension, we performed a quantitative trait locus analysis on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains after they ...
Johns, C +6 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene‐drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub‐study of participants (N = 1874) with hypertension and self‐reported African ancestry to determine whether ...
Philip E. Empey +25 more
wiley +1 more source