Results 91 to 100 of about 3,726,731 (344)

Multipoint quantitative-trait linkage analysis in general pedigrees.

American Journal of Human Genetics, 1998
Multipoint linkage analysis of quantitative-trait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and ...
L. Almasy, J. Blangero
semanticscholar   +1 more source

Quantitative trait loci for physical activity traits in mice

Physiological Genomics, 2008
The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel distance, duration, and speed of exercise. F2animals ( n = 310) derived from high active C57L/J and low active C3H/HeJ
J Timothy, Lightfoot, Michael J, Turner, Daniel, Pomp, Steven R, Kleeberger, Larry J, Leamy   +4 more
openaire   +3 more sources

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci

Molecular Autism, 2012
Background Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common variants with autism susceptibility risk
Davis Lea K, Gamazon Eric R, Kistner-Griffin Emily, Badner Judith A, Liu Chunyu, Cook Edwin H, Sutcliffe James S, Cox Nancy J   +7 more
doaj   +1 more source

Gene and QTL detection in a three-way barley cross under selection by a mixed model with kinship information using SNPs [PDF]

, 2011
Quantitative trait locus (QTL) detection is commonly performed by analysis of designed segregating populations derived from two inbred parental lines, where absence of selection, mutation and genetic drift is assumed.
Casas, Ana M., Ramsay, L., Fred A. van Eeuwijk, Mónica Elía, Bhat, Prasanna R., Malosetti, Marcos, Molina-Cano, José-Luis, Eeuwijk, F.A., van, Martin P. Boer, Luke Ramsay, van Eeuwijk, F.A., Molina-Cano, J.L., Elía, Mónica, Marian Moralejo, Ramsay, Luke, Boer, M., Eeuwijk, Fred A. van, Moralejo, Marian, Ramsay, Luke D., Ana M. Casas, Molina-Cano, José Luis, José-Luis Molina-Cano, Boer, Martin P., Moralejo, María Ángeles, Marcos Malosetti, Malosetti, M., Casas Cendoya, Ana María, Prasanna R. Bhat, Bhat, P., Casas, A., Elia, M., van Eeuwijk, Fred A.   +31 more
core   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

The quantitative genetic basis of sex ratio variation in Nasonia vitripennis : a QTL study [PDF]

, 2010
Our understanding of how natural selection should shape sex allocation is perhaps more developed than for any other trait. However, this understanding is not matched by our knowledge of the genetic basis of sex allocation.
Shuker, DM, West, SA, West, S. A., Knott, SA, Pannebakker, B.A., West, S.A., R. WATT, Watt, R, D. M. SHUKER, Shuker, D. M., S. A. KNOTT, Knott, S. A., Watt, R., Shuker, D.M., B. A. PANNEBAKKER, Pannebakker, B. A., Pannebakker, BA, Knott, S.A., S. A. WEST, Shuker, David Michael, Pannebakker, Bart   +20 more
core   +2 more sources

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet

Advanced Science, EarlyView.
SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv, Jinjin Cheng, Zhen Hu, Qian Lan, Yanjun Yang, Chengcheng Pei, Junhao Luo, Zhuang Li, Peiyong Xin, Jijun Yan, Jinfang Chu, Qian Qian, Zhaosheng Kong, Liang Jiang   +13 more
wiley   +1 more source

Construction of a high-density genetic map using specific-locus amplified fragment sequencing and quantitative trait loci analysis for tillering related traits in Psathyrostachys juncea perennial grass [PDF]

PeerJ
Background Russian wildrye (RWR, Psathyrostachys juncea) is an outcrossing perennial grass that plays a crucial role in foragaing and rangeland restoration due to its tiller producing capabilities, nevertheless, a genetic map has yet to be constructed ...
Yingmei Ma, Yudong Chang, Zhen Li, Zhiqi Gao, Feng Han, Yong Wang, Lan Yun   +6 more
doaj   +2 more sources