Results 71 to 80 of about 3,726,731 (344)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

QTL mapping in autotetraploids using SNP dosage information [PDF]

, 2014
Dense linkage maps derived by analysing SNP dosage in autotetraploids provide detailed information about the location of, and genetic model at, quantitative trait loci.
Christine A. Hackett, Glenn J. Bryan, Bradshaw, John E., Bryan, Glenn J., John E. Bradshaw, Hackett, Christine A.   +5 more
core   +1 more source

Prioritizing quantitative trait loci for root system architecture in tetraploid wheat

Journal of Experimental Botany, 2016
Highlight The genetic variation of root system architecture in the A and B wheat genomes is described, providing the necessary knowledge ultimately to fine-tune the expression of the root system architecture.
M. Maccaferri, Walid M. El-Feki, G. Nazemi, S. Salvi, M. Cane’, M. C. Colalongo, S. Stefanelli, R. Tuberosa   +7 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Methylation quantitative trait loci in the developing brain and their enrichment in schizophrenia-associated genomic regions

Nature Neuroscience, 2015
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n = 166) of human fetal brain samples spanning 56–166 d post-conception, identifying >16,000 fetal brain mQTLs.
E. Hannon, H. Spiers, Joana Viana, R. Pidsley, J. Burrage, Therese M. Murphy, C. Troakes, G. Turecki, M. O’Donovan, L. Schalkwyk, N. Bray, J. Mill   +11 more
semanticscholar   +1 more source

Detection of quantitative trait loci for locomotion and osteochondrosis-related traits in Large White x Meishan pigs. [PDF]

, 2003
Data from the F2 generation of a Large White (LW) 5 Meishan (MS) crossbred population were analysed to detect quantitative trait loci (QTL) for leg and gait scores, osteochondrosis and physis scores.
Lee, G. J., Law, Andy, Archibald, Alan, Nicholson, D, Haley, Chris, Garth, G. B., Barr, A.   +6 more
core  

Efficient QTL detection for nonhost resistance in wild lettuce: backcross inbred lines versus F2 [PDF]

, 2008
In plants, several population types [F2, recombinant inbred lines, backcross inbred lines (BILs), etc.] are used for quantitative trait locus (QTL) analyses.
Stam, P., M. J. W. Jeuken, P. Stam, Pelgrom, K.T.B., K. Pelgrom, Jeuken, M.J.W., Lindhout, P., P. Lindhout   +7 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

CHROMOSOME LOCATION OF GENETIC FACTORS DETERMINIG PHYSIOLOGICAL AND BIOCHEMICAL PROCESSES ASSOCIATED WITH DROUGHT TOLERANCE IN WHEAT TRITICUM AESTIVUM L. [PDF]

Journal of Stress Physiology & Biochemistry, 2012
Drought tolerance is characterized as the most recalcitrant trait to improve for its complexity and considered target for genomic-assisted improvement. A profitable genetic strategy lies in the discovery and exploitation of quantitative trait loci (QTL ...
Osipova S., M. Permyakova, A. Permyakov, T. Pshenichnikova, A. Börner, V. Verkhoturov   +5 more
doaj  

Population differences in transcript-regulator expression quantitative trait loci.

PLoS ONE, 2012
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a disease ...
Pierre R Bushel, Ray McGovern, Liwen Liu, Oliver Hofmann, Ahsan Huda, Jun Lu, Winston Hide, Xihong Lin   +7 more
doaj   +1 more source