Results 81 to 90 of about 3,726,731 (344)

Epistasis: obstacle or advantage for mapping complex traits? [PDF]

, 2010
Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
George Casella, Lauren M McIntyre, Koen J. F. Verhoeven, Casella, G., Verhoeven, K.J.F., Koen J F Verhoeven, Lauren M. McIntyre, McIntyre, L.M.   +7 more
core   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genome-wide Identification of microRNA Expression Quantitative Trait Loci

Nature Communications, 2015
Identification of microRNA expression quantitative trait loci (miR-eQTL) can yield insights into regulatory mechanisms of microRNA transcription, and can help elucidate the role of microRNA as mediators of complex traits.
T. Huan, J. Rong, Chunyu Liu, Xiaoling Zhang, K. Tanriverdi, R. Joehanes, Brian H. Chen, J. Murabito, C. Yao, P. Courchesne, P. Munson, C. O'Donnell, N. Cox, Andrew D. Johnson, M. Larson, D. Levy, J. Freedman   +16 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Identification of potential therapeutic targets for problematic alcohol use using multi-omics dataResearch in context

EBioMedicine
Summary: Background: Problematic alcohol use (PAU) is a serious global health issue with limited treatment options. Although genetic studies have identified genomic regions associated with PAU, the specific causal genes and proteins remain unclear. This
Dong June Lee, Minku Song, Soohyun Lim, Sanghyeon Park, Hyejin Kim, Yeeun Ahn, Faith Choi, Woojae Myung, Hong-Hee Won   +8 more
doaj   +1 more source

Quantitative trait loci markers derived from whole genome sequence data increases the reliability of genomic prediction.

Journal of Dairy Science, 2015
This study investigated the effect on the reliability of genomic prediction when a small number of significant variants from single marker analysis based on whole genome sequence data were added to the regular 54k single nucleotide polymorphism (SNP ...
R. Brøndum, Guosheng Su, L. Janss, G. Sahana, B. Guldbrandtsen, D. Boichard, M. Lund   +6 more
semanticscholar   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Identification and Mode of Inheritance of Quantitative Trait Loci for Secondary Metabolite Abundance in Tomato[OPEN]

The Plant Cell, 2015
Metabolite QTL for secondary metabolism in a Solanum pennelli introgression line population show different modes of inheritance and network properties linking the traits.
Saleh Alseekh, Takayuki Tohge, R. Wendenberg, F. Scossa, Nooshin Omranian, J. Li, Sabrina Kleessen, Patrick Giavalisco, T. Pleban, B. Mueller-Roeber, D. Zamir, Z. Nikoloski, A. Fernie   +12 more
semanticscholar   +1 more source

Quantitative trait loci mapping of panicle traits in rice.

Molecular biology research communications, 2019
In this study 90 individuals of recombinant inbred lines (RILs) were developed by crossing subspecies of japonica rice cultivar, 'Nagdong' and an indica type cultivar, 'Cheongcheong'. These individuals were used to identify the quantitative trait loci of panicle traits using SSR markers.
Jia, Baoyan, Zhao, Xinhua, Qin, Yang, Irfan, Muhammad, Kim, Tae-heon, Wang, Bolun, Wang, Shu, Sohn, Jae   +7 more
openaire   +2 more sources

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source