Results 61 to 70 of about 3,726,731 (344)

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci

open access: yesNucleic Acids Research, 2018
Quantitative trait locus (QTL) mapping of molecular phenotypes such as metabolites, lipids and proteins through genome-wide association studies represents a powerful means of highlighting molecular mechanisms relevant to human diseases.
D. Stacey   +8 more
semanticscholar   +1 more source

A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index [PDF]

open access: yes, 2007
Osteoporosis, resulting from progressive loss of structural bone during the period of egg-laying in hens, is associated with an increased susceptibility to bone breakage.
Preisinger, R.   +20 more
core   +1 more source

Mapping and Validation of Quantitative Trait Loci for Root Architectural Traits in Rice (Oryza sativa) under Non-Stress and Salinity Stress Conditions

open access: yesTropical Agricultural Research, 2018
Root architectural traits are governed by many genes exhibiting polygenic inheritance. The dissection of the genetic basis of root traits could be achieved by mapping of quantitative trait loci (QTLs) using molecular markers.
D. R. Gimhani   +3 more
doaj   +1 more source

Mapping carcass and meat quality QTL on Sus Scrofa chromosome 2 in commercial finishing pigs [PDF]

open access: yes, 2009
Quantitative trait loci (QTL) affecting carcass and meat quality located on SSC2 were identified using variance component methods. A large number of traits involved in meat and carcass quality was detected in a commercial crossbred population: 1855 pigs ...
Knol, A.J.   +23 more
core   +1 more source

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [PDF]

open access: yes, 2014
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.
Paternoster, Lavinia   +999 more
core   +4 more sources

A Bayesian approach to detect QTL affecting a simulated binary and quatitative trait [PDF]

open access: yes, 2011
Background - We analyzed simulated data from the 14th QTL-MAS workshop using a Bayesian approach implemented in the program iBay. The data contained individuals genotypes for 10,031 SNPs and phenotyped for a quantitative and a binary trait. Results - For
Janss, L.L.G.   +7 more
core   +2 more sources

Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana [PDF]

open access: yes, 2008
Background Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes.
Fu, Jingyuan   +23 more
core   +1 more source

A Latent Variable Approach to Multivariate Quantitative Trait Loci [PDF]

open access: yes, 2010
A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and ...
Päivi Komulainen   +3 more
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

On Flexible finite polygenic models for multiple-trait evaluation [PDF]

open access: yes, 2002
Finite polygenic models (FPM) might be an alternative to the infinitesimal model (TIM) for the genetic evaluation of pedigreed multiple-generation populations for multiple quantitative traits.
Bink, M.C.A.M.
core   +1 more source

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