Results 111 to 120 of about 84,882 (161)

Quantitative trait loci and psychopharmacology

Journal of Psychopharmacology, 1991
Unlike simple Mendelian characteristics, individual differences in behavior, including behavioral responses to drugs, are generally distributed continuously, show substantial non-genetic as well as genetic influence, and appear to be influenced by many genes rather than one or two major genes.
Plomin, R, McClearn, G E, Gora-Maslak, G
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Parameters of Quantitative Trait Loci

Critical Reviews™ in Eukaryotic Gene Expression, 2007
Most traits of medical relevance follow quantitative inheritance patterns. The genetic dissection of quantitative traits poses special challenges for geneticists mainly because of low penetrance and gene-gene and gene-environment interactions. Emerging genome resources and technologies are enabling systematic investigation of the genetic architecture ...
Jian, Yan, Weikuan, Gu
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Quantitative Trait Loci Mapping

2008
This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping.
Dong-Hai, Xiong, Jian-Feng, Liu, Yan-Fang, Guo, Yan, Guo, Tie-Lin, Yang, Hui, Jiang, Yuan, Chen, Fang, Yang, Robert R, Recker, Hong-Wen, Deng   +9 more
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Quantitative trait loci for baseline erythroid traits

Mammalian Genome, 2006
A substantial genetic contribution underlies variation in baseline peripheral blood counts. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline erythroid parameters in F2 intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice.
Peters, L L, Lambert, A J, Zhang, W, Churchill, G A, Brugnara, C, Platt, O S   +5 more
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Quantitative trait loci for behavioural traits in chickens

Livestock Production Science, 2005
Abstract The detection of quantitative trait loci (QTL) of behavioural traits has mainly been focussed on mouse and rat. With the rapid development of molecular genetics and the statistical tools, QTL mapping for behavioural traits in farm animals is developing.
Buitenhuis, A.J., Rodenburg, T.B., Siwek, M.Z., Cornelissen, S.J.B., Nieuwland, M.G.B., Crooijmans, R.P.M.A., Groenen, M.A.M., Koene, P., Bovenhuis, H., van der Poel, J.J.   +9 more
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Quantitative trait loci in Drosophila

Nature Reviews Genetics, 2001
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been
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Mapping Quantitative Trait Loci in Yeast

Cold Spring Harbor Protocols, 2017
Natural Saccharomyces strains isolated from the wild differ quantitatively in molecular and organismal phenotypes. Quantitative trait loci (QTL) mapping is a powerful approach for identifying sequence variants that alter gene function. In yeast, QTL mapping has been used in designed crosses to map functional polymorphisms. This approach, outlined here,
Gianni, Liti, Jonas, Warringer, Anders, Blomberg   +2 more
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Analysis of Quantitative Trait Loci

2016
Although the term quantitative trait locus (QTL) strictly refers merely to a genetic variant that causes changes in a quantitative phenotype such as height, QTL analysis more usually describes techniques used to study oligogenic or polygenic traits where each identified locus contributes a relatively small amount to the genetic determination of the ...
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Mapping Multiple Quantitative Trait Loci for Ordinal Traits

Behavior Genetics, 2004
Many complex traits in humans and other organisms show ordinal phenotypic variation but do not follow a simple Mendelian pattern of inheritance. These ordinal traits are presumably determined by many factors, including genetic and environmental components. Several statistical approaches to mapping quantitative trait loci (QTL) for such traits have been
Nengjun, Yi, Shizhong, Xu, Varghese, George, David B, Allison   +3 more
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Analysis of Quantitative Trait Loci

2008
Diseases with complex inheritance are characterized by multiple genetic and environmental factors that often interact to produce clinical symptoms. In addition, etiological heterogeneity (different risk factors causing similar phenotypes) obscure the inheritance pattern among affected relatives and hamper the feasibility of gene-mapping studies.
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