Results 111 to 120 of about 3,726,731 (344)

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Identification of Gene Variants Associated with Melanocyte Stem Cell Differentiation in Mice Predisposed for Hair Graying

G3: Genes, Genomes, Genetics, 2019
Age-related hair graying is caused by malfunction in the regenerative potential of the adult pigmentation system. The retention of hair color over the life of an organism is dependent on the ability of the melanocyte stem cells and their progeny to ...
Allison C. Fialkowski, Denise J. Levy, Dawn E. Watkins-Chow, Joseph W. Palmer, Roshan Darji, Hemant K. Tiwari, William J. Pavan, Melissa L. Harris   +7 more
doaj   +1 more source

QTL IciMapping: Integrated software for genetic linkage map construction and quantitative trait locus mapping in biparental populations

, 2015
QTL IciMapping is freely available public software capable of building high-density linkage maps and mapping quantitative trait loci (QTL) in biparental populations.
L. Meng, Hui-Hui Li, Luyan Zhang, Jian-Kang Wang   +3 more
semanticscholar   +1 more source

Quantitative trait loci affecting reproductive phenology in peach

BMC Plant Biology, 2014
BackgroundThe reproductive phenology of perennial plants in temperate climates is largely conditioned by the duration of bud dormancy, and fruit developmental processes.
J. Romeu, A. Monforte, Gerardo Sánchez, A. Granell, J. García-Bruntón, M. Badenes, G. Ríos   +6 more
semanticscholar   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Linkage of DNA methylation quantitative trait loci to human cancer risk.

Cell Reports, 2014
Epigenetic regulation and, in particular, DNA methylation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes ...
H. Heyn, Sergi Sayols, C. Moutinho, E. Vidal, J. Sanchez-Mut, O. Stefansson, E. Nadal, S. Moran, J. Eyfjord, E. González-Suárez, M. Pujana, M. Esteller   +11 more
semanticscholar   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Overcoming collaboration barriers in quantitative trait loci analysis

Cell Genomics
In this issue of Cell Genomics, Choi et al.1 report a novel approach, privateQTL, which leverages secure multiparty computation (MPC) to enable federated expression quantitative trait loci (eQTL) mapping across institutions without compromising data ...
Wen Zhang, Xiaohong Wu, Jing Gong
doaj   +1 more source

Heritability and tissue specificity of expression quantitative trait loci.

PLoS Genetics, 2006
Variation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling and linkage analysis to the regulation of gene
Enrico Petretto, Jonathan Mangion, Nicholas J Dickens, Stuart A Cook, Mande K Kumaran, Han Lu, Judith Fischer, Henrike Maatz, Vladimir Kren, Michal Pravenec, Norbert Hubner, Timothy J Aitman   +11 more
doaj   +1 more source

Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart

PLoS ONE, 2014
In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition.
T. Koopmann, M. Adriaens, P. Moerland, R. Marsman, M. L. Westerveld, S. Lal, Taifang Zhang, Christine Q. Simmons, I. Baczkó, C. D. dos Remedios, N. Bishopric, A. Varró, A. George, E. Lodder, C. Bezzina   +14 more
semanticscholar   +1 more source