Results 141 to 150 of about 282,753 (347)

Enrichment of Cis-Regulatory Gene Expression SNPs and Methylation Quantitative Trait Loci Among Bipolar Disorder Susceptibility Variants

Molecular Psychiatry, 2012
We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing disease risk.
E. Gamazon, J. Badner, L. Cheng, C. Zhang, D. Zhang, N. Cox, E. Gershon, J. Kelsoe, T. Greenwood, C. Nievergelt, C. Chen, R. Mckinney, P. Shilling, N. Schork, En. Smith, C. Bloss, J. Nurnberger, H. Edenberg, T. Foroud, D. Koller, WA Scheftner, W. Coryell, J. Rice, W. Lawson, E. Nwulia, M. Hipolito, W. Byerley, F. McMahon, T. Schulze, W. Berrettini, J. Potash, P. Zandi, PB Mahon, M. McInnis, S. Zöllner, P. Zhang, D. Craig, S. Szelinger, T. Barrett, C. Liu   +39 more
semanticscholar   +1 more source

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M. McKeigue   +9 more
wiley   +1 more source

Alfalfa genomic selection for different stress‐prone growing regions

The Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Alfalfa (Medicago sativa L.) selection for stress‐prone regions has high priority for sustainable crop–livestock systems. This study assessed the genomic selection (GS) ability to predict alfalfa breeding values for drought‐prone agricultural sites of Algeria, Morocco, and Argentina; managed‐stress (MS) environments of Italy featuring moderate
Paolo Annicchiarico, Nelson Nazzicari, Abdelaziz Bouizgaren, Taoufik Hayek, Meriem Laouar, Monica Cornacchione, Daniel Basigalup, Cristina Monterrubio Martin, Edward Charles Brummer, Luciano Pecetti   +9 more
wiley   +1 more source

PEMETAAN QUANTITATIVE TRAIT LOCI UNTUK SIFAT BERSKALA KATEGORIK

Jurnal Ilmu Pertanian Indonesia, 2007
Genes or regions on chromosome underlying a quantitative trait are called quantitative trait loci (QTL). Characterizing genes controlling quantitative trait on their position in chromosome and their effect on trait is through a process called QTL mapping.
Farit Mochamad Afendi
doaj  

Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine

BMC Genetics, 2011
Background Increased disease resistance through improved general immune capacity would be beneficial for the welfare and productivity of farm animals. T lymphocyte subpopulations in peripheral blood play an important role in immune capacity and disease ...
Wang Zhi-Peng, Gong Yuan-Fang, Liu Jian-Feng, Lu Xin, Liu Yang, Zhang Qin   +5 more
doaj   +1 more source

A new method for Quantitative Trait Loci Detection [PDF]

, 2010
We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL on the interval $[0,T]$ representing a chromosome (a QTL denotes a quantitative trait locus, i.e. a gene with quantitative effect on a trait).
DELMAS, Céline, Rabier, Charles-Elie
core   +1 more source

m6A‐mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly

Autism Research, EarlyView.
ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD‐DM) seen at three years of age is associated with co‐occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD‐DM have yet to be delineated. In this study, we identified additional ASD‐DM candidate genes
Sierra S. Nishizaki, Nicholas K. Haghani, Gabriana N. La, Natasha Ann F. Mariano, José M. Uribe‐Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G. Amaral, Megan Y. Dennis   +10 more
wiley   +1 more source

Genome‐wide association analysis identified consistent QTL for seed yield in a soybean diversity panel tested across multiple environments

The Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Improving seed yield is one of the main targets of soybean [Glycine max (L.) Merr.] breeding. Identification of loci that influence productivity and understanding their genetic mechanism will help marker‐assisted trait introgression. The present study evaluated a diverse panel of 541 soybean genotypes consisting of three maturity groups (MGs ...
Habtamu Ayalew, William Schapaugh, Tri Vuong, Henry T. Nguyen   +3 more
wiley   +1 more source

Efficiency of population structures for mapping of Mendelian and imprinted quantitative trait loci in outbred pigs using variance component methods

Genetics Selection Evolution, 2005
In a simulation study different designs for a pure line pig population were compared for efficiency of mapping QTL using the variance component method. Phenotypes affected by a Mendelian QTL, a paternally expressed QTL, a maternally expressed QTL or by a
van Arendonk Johan AM, Janss Luc LG, Bovenhuis Henk, Heuven Henri CM   +3 more
doaj   +1 more source

High resolution of quantitative traits into multiple loci via interval mapping. [PDF]

, 1994
Rick Jansen, P. Stam
openalex   +1 more source