Results 141 to 150 of about 313,777 (344)

Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks

Research in Molecular Medicine, 2015
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions.
Ali Kazemipour, Bahram Goliaei, Hamid Pezeshk, Behjat Kalantari khandani   +3 more
doaj  

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Multiple-Trait Mapping of Quantitative Trait Loci After Selective Genotyping Using Logistic Regression [PDF]

, 1999
John Henshall, Michael E. Goddard
openalex   +1 more source

Addressing Heterogeneity in Binge Eating Disorder: A Cluster Analysis Approach Based on Age of Onset, Clinical and Psychopathological Features

European Eating Disorders Review, EarlyView.
ABSTRACT Objective This study investigates clinical heterogeneity in patients with binge eating disorder (BED) and its association with treatment outcomes. Methods A two‐step cluster analysis was conducted on a clinical sample of 196 BED patients, using an agglomerative hierarchical procedure based on both categorical and quantitative measures ...
Lucía Camacho‐Barcia, Lia T. Sánchez‐Salido, Jessica Jiménez del Toro, Roser Granero, Isabel Sánchez, Kim Supit, Nadia Micali, Katrin Elisabeth Giel, Susana Jiménez‐Murcia, Stephan Zipfel, Fernando Fernández‐Aranda   +10 more
wiley   +1 more source

Linkage Disequilibrium Analysis of Biallelic DNA Markers, Human Quantitative Trait Loci, and Threshold-Defined Case and Control Subjects [PDF]

, 2000
Nicholas J. Schork, Swapan K. Nath, Daniele Fallin, Aravinda Chakravarti   +3 more
openalex   +1 more source

The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift

, 2010
By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift.
Abramowitz M., Barton N. H., Bulmer M. G., Bürger R., Crow J. F., Ewens W. J., Falconer D. S., Gavrilets S., Harold P. de Vladar, Kimura M., Kondrashov A. S., Lynch M., Lynch M., Nick H. Barton, Rattray M., Turelli M., Turelli M., Wright S., Wright S.   +18 more
core   +2 more sources

QTL-seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations.

The Plant Journal, 2013
H. Takagi, A. Abe, Kentaroh Yoshida, S. Kosugi, S. Natsume, Chikako Mitsuoka, Aiko Uemura, Hiroe Utsushi, Muluneh Tamiru, Shohei Takuno, H. Innan, L. Cano, S. Kamoun, R. Terauchi   +13 more
semanticscholar   +1 more source

Spiritual Cannibalism in HRD: How Workplace Spirituality Devours Sacred Traditions

Human Resource Development Quarterly, EarlyView.
ABSTRACT This paper interrogates how the discourse of workplace spirituality in human resource development (HRD) operates as a tool of colonization. Through a systematic review of 48 articles published between 1997 and March 2025, the study uncovers recurring patterns of spiritual appropriation in which non‐Western traditions are detached from their ...
Shoaib Ul‐Haq
wiley   +1 more source

Exploring the Link Between Psoriasis and Genetic Predictors of Cardiac Magnetic Resonance Traits: A Bidirectional Mendelian Randomization Study

iNew Medicine, EarlyView.
ABSTRACT Psoriasis is a chronic autoimmune disease characterized by systemic inflammation and skin involvement, affecting millions of individuals worldwide. However, few studies have evaluated whether psoriasis and cardiac magnetic resonance imaging (CMR) traits share a common genetic basis.
Junlin Yang, Pengzhan Yin, Shutian An, Zhanglei Li, Yewen Jiang, Jun Wang, Yongqiang Yu, Ren Zhao, Xiaohu Li   +8 more
wiley   +1 more source