Results 151 to 160 of about 3,726,731 (344)

Molecular characterisation of QTLs controlling fatness in pigs [PDF]

, 2002
This thesis deals with the identification of genes controlling intramuscular fat and backfat thickness. Markers linked to quantitative trait loci (QTL) for these traits in the cross between Meishan x Large White breeds will lead to the identification of ...
Rattink, A.P.
core  

Linkage mapping and quantitative trait loci analysis of sweetness and other fruit quality traits in papaya

, 2019
ackground: The identification and characterisation of quantitative trait loci (QTL) is an important step towards identifying functional sequences underpinning important crop traits and for developing accurate markers for selective breeding strategies. In
Kanchana-udomkan, Chutchamas, Bar, Ido, Ford, Rebecca, Nantawan, Usana   +3 more
core   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Mapping quantitative trait loci for kernel composition in almond

BMC Genetics, 2012
Background Almond breeding is increasingly taking into account kernel quality as a breeding objective. Information on the parameters to be considered in evaluating almond quality, such as protein and oil content, as well as oleic acid and tocopherol ...
i Forcada Carolina, i Martí Àngel, i Company Rafel   +2 more
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

Frontiers in Molecular Neuroscience
IntroductionMetabolic syndrome (MetS) and Parkinson’s disease (PD) share common pathophysiological and molecular impairments related to high PD incidence in MetS patients.
Guenson Chevalier, Lucas Udovin, Matilde Otero-Losada, Sofia Bordet, Sofia Bordet, Santiago Perez-Lloret, Santiago Perez-Lloret, Francisco Capani, Francisco Capani   +8 more
doaj   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Secure and federated quantitative trait loci mapping with privateQTL

Cell Genomics
Summary: Understanding the relationship between genotypes and phenotypes is crucial for advancing personalized medicine. Expression quantitative trait loci (eQTL) mapping plays a significant role by correlating genetic variants to gene expression levels.
Yoolim Annie Choi, Yebin Kim, Peihan Miao, Tuuli Lappalainen, Gamze Gürsoy   +4 more
doaj   +1 more source