Results 171 to 180 of about 3,758,767 (255)

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

Origins and implications of intron retention quantitative trait loci in human tissues. [PDF]

Am J Hum Genet
Park E, Xing Y.
europepmc   +1 more source

Determinants of Community Resilience: A Multi‐Level Synthesis of Empirical and Conceptual Evidence

Sustainable Development, EarlyView.
ABSTRACT Community resilience research remains fragmented across disciplines, with limited integration of empirical evidence and conceptual scholarship. This study addresses this gap through a directed content analysis of 48 empirical case studies and 39 conceptual and review publications from diverse geographical and hazard contexts.
Anamol Neupane, Seweryn Zielinski, Iroda Mukhammadieva   +2 more
wiley   +1 more source

Quantitative trait loci analysis identifying novel genomic regions for off-target dicamba tolerance in soybean [Glycine max (L.) Merr.]. [PDF]

BMC Plant Biol
Lee D, do Nascimento EF, Acuna-Galindo A, Harrison D, Florez-Palacios L, Marmo RG, Wu C, Rogers D, Ravelombola F, Lin F, Shannon JG, Nguyen HT, Vieira CC.   +12 more
europepmc   +1 more source

Multiscale Effects of Environmentally Relevant Mixtures Containing Two Estrogenic Endocrine Disruptors, Chlordecone and Propylparaben, in Hydra vulgaris Pallas, 1766

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates the chronic effects of chlordecone (CLD) and propylparaben (PP), two pro‐estrogenic endocrine disruptors, on Hydra vulgaris Pallas, 1766 using a multiscale approach over a 14‐day exposure period. Environmentally relevant concentrations of CLD (0.5, 5, 20 μg L−1) and PP (0.01, 0.05, 0.40 μg L−1) were tested individually ...
Magali Domallain, Romain Colpaert, Xavier Moreau, Laetitia De Jong, Karim Benbrahim, Raphael Coatmeur, Valérie Pique, Maxime Robin, Pierre‐Henri Villard   +8 more
wiley   +1 more source

A new insight of hypertrophic cardiomyopathy: integrated analysis of differentially expressed genes, expression quantitative trait loci, and mendelian randomization. [PDF]

J Cardiothorac Surg
Guan Y, Wang H, Huang H, Liang D, Zhang T, Liu H.   +5 more
europepmc   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Integrating genome-wide association studies with quantitative trait loci prioritised <i>PSMA4</i> as a risk gene for pneumonia. [PDF]

ERJ Open Res
Jin Y, Xu J, Hu Q, Li J, Wang Y, Cao B.
europepmc   +1 more source

Biology, ecology, and conservation of the Italian hare Lepus corsicanus: a review

Wildlife Biology, EarlyView.
The Italian hare Lepus corsicanus, an endemic lagomorph of Italy, serves as a critical case study in evolutionary biology and conservation. Once taxonomically debated, modern genetic and morphological analyses confirm its status as a distinct Pleistocene lineage restricted to the central‐southern Italian Peninsula and Sicily.
Pierangelo Freschi, Valter Trocchi
wiley   +1 more source

Genetic analysis and quantitative trait loci detection of udder traits in Jersey cattle. [PDF]

BMC Genomics
Lu X, Long M, Zhu H, Jiang H, Zhou F, Wang B, Liu Z, Yang Z.   +7 more
europepmc   +1 more source