Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping
BMC Bioinformatics, 2011 Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
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Semiparametric Quantitative-Trait-Locus Mapping: I. on Functional Growth Curves [PDF]
, 2004 The genetic study of certain quantitative traits in growth curves as a function of time has recently been of major scientific interest to explore the developmental evolution processes of biological subjects.
Chen, Ying Qing, Wu, Rongling
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Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus [PDF]
, 2007 Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong genetic component determining susceptibility for renal disease and, by inference, the ...
Chi, L. +7 more
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Model selection for quantitative trait locus analysis in polyploids [PDF]
Proceedings of the National Academy of Sciences, 2000 Over the years, substantial gains have been made in locating regions of agricultural genomes associated with characteristics, diseases, and agroeconomic traits. These gains have relied heavily on the ability to statistically estimate the association between DNA markers and regions of a genome (quantitative trait loci or QTL) related to a particular ...
Bruce A. Craig, Rebecca W. Doerge
openaire +3 more sources
Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
Single nucleotide polymorphisms in the CDH18 gene affect growth traits in Hu sheep
Animal Research and One Health, EarlyView., 2023 Abstract Growth traits are critical economic traits in sheep. Genetic polymorphism has a great influence on the improvement of sheep traits. The aim of this study was to analyze the effect of cadherin 18 (CDH18) gene polymorphisms on growth traits in Hu sheep.
Tianyi Liu +5 more
wiley +1 more source
Searching for interacting QTL in related populations of an outbreeding species [PDF]
, 2009 Many important crop species are outbreeding. In outbreeding species the search for genes affecting traits is complicated by the fact that in a single cross up to four alleles may be present at each locus.
Bink, M.C.A.M. +3 more
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Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
Human Molecular Genetics, 2015 Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting from the age-associated loss of cartilage. Well-powered genetic studies have identified a number of DNA polymorphisms that are associated with OA ...
M. Rushton +9 more
semanticscholar +1 more source
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Additive Genetic Variation under Intraspecific Competition and Stabilizing Selection: A Two-Locus Study [Revised June 2002] [PDF]
, 2002 A diallelic two-locus model is investigated in which the loci determine the genotypic value of a quantitative trait additively. Fitness has two components: stabilizing selection on the trait and a frequency-dependent component, as induced for instance if
Buerger, R.
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