Developmental dyslexia: Genetic dissection of a complex cognitive trait [PDF]
Developmental dyslexia, a specific impairment of reading ability despite adequate intelligence and educational opportunity, is one of the most frequent childhood disorders.
DeFries, J., Fisher, S.
core +2 more sources
Bayesian Quantitative Trait Locus Mapping Using Inferred Haplotypes [PDF]
Abstract We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood factorizes ...
Durrant, C, Mott, R
openaire +3 more sources
Development of a Next-Generation NIL Library in Arabidopsis Thaliana for Dissecting Complex Traits [PDF]
The identification of the loci and specific alleles underlying variation in quantitative traits is an important goal for evolutionary biologists and breeders.
Bauerle, William L. +8 more
core +3 more sources
Detection of QTLs controlling heading date in the process of rice development at two environments
Heading date (HD) is a major determinant of the regional and seasonal adaptation of rice varieties. In order to elucidate the quantitative trait loci (QTL) for HD in the process of rice development, a doubled haploid (DH) population was employed to map ...
BAO Jin-song +3 more
doaj +1 more source
Threshold and power for Quantitative Trait Locus detection [PDF]
We propose several new methods to calculate threshold and power for Quantitative Trait Locus (QTL) detection. They are based on asymptotic theoretical results presented in Rabier et al. (2009) . The asymptotic validity is checked by simulations.
Azaïs, Jean-Marc +3 more
core +1 more source
Near-periodic substitution and the genetic variance induced by environmental change [PDF]
We investigate a model that describes the evolution of a diploid sexual population in a changing environment. Individuals have discrete generations and are subject to selection on the phenotypic value of a quantitative trait, which is controlled by a ...
Barton +29 more
core +3 more sources
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Population Genetic Signature of Polygenic Local Adaptation [PDF]
Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals.
Berg, Jeremy J., Coop, Graham
core +8 more sources
Mapping resistant QTLs for rice sheath blight disease with a doubled haploid population
Sheath blight (SB) disease, caused by Rhizoctonia solani Kühn, is one of the most serious diseases causing rice (Oryza sativa L.) yield loss worldwide. A doubled haploid (DH) population was constructed from a cross between a japonica variety CJ06 and an ...
Yu-xiang ZENG +6 more
doaj +1 more source
Genetic structure and molecular mechanism underlying the stalk lodging traits in maize (Zea mays L.)
Stalk lodging seriously affects yield and quality of crops, and it can be caused by several factors, such as environments, developmental stages, and internal chemical components of plant stalks.
Shuai Wang +6 more
doaj +1 more source

