Results 41 to 50 of about 294,293 (342)

Genomic prediction from observed and imputed high-density ovine genotypes

Genetics Selection Evolution, 2017
Background Genomic prediction using high-density (HD) marker genotypes is expected to lead to higher prediction accuracy, particularly for more heterogeneous multi-breed and crossbred populations such as those in sheep and beef cattle, due to providing ...
Nasir Moghaddar, Andrew A. Swan, Julius H. J. van der Werf   +2 more
doaj   +1 more source

The Population Genetic Signature of Polygenic Local Adaptation [PDF]

, 2014
Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals.
Berg, Jeremy J., Coop, Graham
core   +8 more sources

Identification of QTL Controlling Flooding Tolerance in Reducing Soil Conditions in Maize (Zea mays L.) Seedlings

Plant Production Science, 2006
We investigated the tolerance to flooding in reducing conditions of five maize inbred lines and identified a quantitative trait locus (QTL) for the trait. Flooding treatment with 0.1% to 0.4% starch solution for 14 d reduced soil redox potential to about
Yoshiro Mano, Masanori Muraki, Tadashi Takamizo   +2 more
doaj   +1 more source

SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values

BMC Genetics, 2006
Background With the recent advances in high-throughput genotyping technologies that allow for large-scale association mapping of human complex traits, promising statistical designs and methods have been emerging.
Lemire Mathieu
doaj   +1 more source

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

G3: Genes, Genomes, Genetics, 2016
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping.
Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright   +4 more
doaj   +1 more source

Controlling the Overfitting of Heritability in Genomic Selection through Cross Validation. [PDF]

, 2017
In genomic selection (GS), all the markers across the entire genome are used to conduct marker-assisted selection such that each quantitative trait locus of complex trait is in linkage disequilibrium with at least one marker.
Jia, Zhenyu
core   +2 more sources

WASP: allele-specific software for robust molecular quantitative trait locus discovery

Nature Methods, 2015
Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts.
Bryce van de Geijn, G. McVicker, Y. Gilad, J. Pritchard   +3 more
semanticscholar   +1 more source

A compendium of uniformly processed human gene expression and splicing quantitative trait loci

Nature Genetics, 2021
Many gene expression quantitative trait locus (eQTL) studies have published their summary statistics, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and co-localization.
N. Kerimov, J. Hayhurst, Kateryna Peikova, J. Manning, P. Walter, Liis Kolberg, Marija Samoviča, M. P. Sakthivel, I. Kuzmin, S. Trevanion, Tony Burdett, S. Jupp, H. Parkinson, I. Papatheodorou, Andrew D. Yates, D. Zerbino, Kaur Alasoo   +16 more
semanticscholar   +1 more source

Threshold and power for Quantitative Trait Locus detection [PDF]

, 2010
We propose several new methods to calculate threshold and power for Quantitative Trait Locus (QTL) detection. They are based on asymptotic theoretical results presented in Rabier et al. (2009) . The asymptotic validity is checked by simulations.
Azaïs, Jean-Marc, DELMAS, Céline, Elsen, Jean-Michel, Rabier, Charles-Elie   +3 more
core   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source