Results 41 to 50 of about 141,382 (327)

Genomic prediction from observed and imputed high-density ovine genotypes

Genetics Selection Evolution, 2017
Background Genomic prediction using high-density (HD) marker genotypes is expected to lead to higher prediction accuracy, particularly for more heterogeneous multi-breed and crossbred populations such as those in sheep and beef cattle, due to providing ...
Nasir Moghaddar, Andrew A. Swan, Julius H. J. van der Werf   +2 more
doaj   +1 more source

Optimizing expression quantitative trait locus mapping workflows for single-cell studies

Genome Biology, 2021
Background Single-cell RNA sequencing (scRNA-seq) has enabled the unbiased, high-throughput quantification of gene expression specific to cell types and states.
Anna S. E. Cuomo, Giordano Alvari, Christina B. Azodi, single-cell eQTLGen consortium, Davis J. McCarthy, Marc Jan Bonder   +5 more
doaj   +1 more source

SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values

BMC Genetics, 2006
Background With the recent advances in high-throughput genotyping technologies that allow for large-scale association mapping of human complex traits, promising statistical designs and methods have been emerging.
Lemire Mathieu
doaj   +1 more source

Finding the sources of missing heritability in a yeast cross [PDF]

, 2012
For many traits, including susceptibility to common diseases in humans, causal loci uncovered by genetic mapping studies explain only a minority of the heritable contribution to trait variation. Multiple explanations for this "missing heritability" have been proposed.
arxiv   +1 more source

Identification of QTL Controlling Flooding Tolerance in Reducing Soil Conditions in Maize (Zea mays L.) Seedlings

Plant Production Science, 2006
We investigated the tolerance to flooding in reducing conditions of five maize inbred lines and identified a quantitative trait locus (QTL) for the trait. Flooding treatment with 0.1% to 0.4% starch solution for 14 d reduced soil redox potential to about
Yoshiro Mano, Masanori Muraki, Tadashi Takamizo   +2 more
doaj   +1 more source

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

G3: Genes, Genomes, Genetics, 2016
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping.
Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright   +4 more
doaj   +1 more source

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension [PDF]

Genes, 2020
Expression quantitative trait loci (eQTL) can provide a link between disease susceptibility variants discovered by genetic association studies and biology. To date, eQTL mapping studies have been primarily conducted in healthy individuals from population-based cohorts.
Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, null on behalf of The NIHR BioResource—Rare Diseases Consortium, null UK PAH Cohort Study Consortium   +12 more
openaire   +6 more sources

InDelGT: An integrated pipeline for extracting indel genotypes for genetic mapping in a hybrid population using next‐generation sequencing data

Applications in Plant Sciences, Volume 10, Issue 6, November-December 2022., 2022
Abstract Premise Although several software packages are available for genotyping insertion/deletion (indel) polymorphisms in genomes using next‐generation sequencing data, simultaneously calling indel genotypes across many individuals for use in genetic mapping remains challenging. Methods and Results We present an integrated pipeline, InDelGT, for the
Zhiliang Pan, Jinpeng Zhang, Shengjun Bai, Zhiting Li, Chunfa Tong   +4 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

A general approximation for the dynamics of quantitative traits [PDF]

, 2015
Selection, mutation and random drift affect the dynamics of allele frequencies and consequently of quantitative traits. While the macroscopic dynamics of quantitative traits can be measured, the underlying allele frequencies are typically unobserved. Can we understand how the macroscopic observables evolve without following these microscopic processes?
arxiv   +1 more source