Quantitative genetics of disease traits [PDF]
Journal of Animal Breeding and Genetics, 2015 SummaryJohn James authored two key papers on the theory of risk to relatives for binary disease traits and the relationship between parameters on the observed binary scale and an unobserved scale of liability (James Annals of Human Genetics, 1971; 35: 47; Reich, James and Morris Annals of Human Genetics, 1972; 36: 163). These two papers are John James’
Wray, N. R., Visscher, P. M.
openaire +5 more sources
Nature Genetics, 2018 Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 ...
M. Kanai +12 more
semanticscholar +1 more source
Mapping quantitative trait loci and identification of genes that control fatness in poultry [PDF]
, 2002 Chicken genomics has benefited from the rapid technological advances in the genomics of model organisms and man. A number of resources and approaches are now well established, in the chicken, including genetic markers and maps (both genetic and physical),
Hocking, Paul M +3 more
core +1 more source
Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia
Journal of Lipid Research, 2004 Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD).
Heidi E. Lilja +10 more
doaj +1 more source
Strong genetic influences on the stability of autistic traits in childhood [PDF]
, 2014 Objective: Disorders on the autism spectrum, as well as autistic traits in the general population, have been found to be both highly stable across age and highly heritable at individual ages.
Ronald, Angelica +18 more
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Chromatin interaction maps reveal genetic regulation for quantitative traits in maize
Nature Communications, 2019 Chromatin loops connect regulatory elements to their target genes. They serve as bridges between transcriptional regulation and phenotypic variation in mammals.
Yong Peng +12 more
semanticscholar +1 more source
Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age [PDF]
, 2012 Background Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect.
Simon Baron-Cohen +20 more
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Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]
, 2014 The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M +6 more
core +1 more source
Genome-Assisted Prediction of Quantitative Traits Using the R Package sommer
PLoS ONE, 2016 Most traits of agronomic importance are quantitative in nature, and genetic markers have been used for decades to dissect such traits. Recently, genomic selection has earned attention as next generation sequencing technologies became feasible for major ...
G. Covarrubias-Pazaran
semanticscholar +1 more source
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
George Casella +7 more
core +3 more sources