Results 161 to 170 of about 1,612,573 (290)

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

open access: yesAngewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie   +14 more
wiley   +2 more sources

The Enzymatic Mechanism of OAS: How Metal Ions and Quantum Effects Help Activate Innate Immunity. [PDF]

open access: yesACS Omega
Kats P   +11 more
europepmc   +1 more source

Quantum Solution of Coordination Problems [PDF]

open access: yes
We present a quantum solution to coordination problems that can be implemented with present technologies. It provides an alternative to existing approaches, which rely on explicit communication, prior commitment or trusted third parties.
Bernardo A. Huberman   +1 more
core  

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

open access: yesAngewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang   +12 more
wiley   +2 more sources

The evaluation system of green mining based on quantum immune algorithm and neural network [PDF]

open access: yesProceedings of the 3rd International Conference on Advances in Energy and Environmental Science 2015, 2015
Linna Li, Dongwang Zhong
openaire   +1 more source

Quantum computing topological invariants of two-dimensional quantum matter

open access: yes
Quantum algorithms provide a potential strategy for solving computational problems that are intractable by classical means. Computing the topological invariants of topological matter is one central problem in research on quantum materials, and a variety ...
Niedermeier, Marcel   +2 more
core   +1 more source

Expanding High‐Fidelity Multiplexing in Ultrasensitive Single‐Molecule Protein Detection via Proximity Barcoding

open access: yesAngewandte Chemie, EarlyView.
We develop an ultrasensitive, high‐accuracy multiplex protein detection platform integrating high‐throughput single‐molecule protein detection with proximity ligation. Using paired DNA barcodes, this platform breaks the digital immunoassay multiplexing ceiling imposed by cross‐reactivity and fluorescence spectral overlap, providing a broadly accessible
Chi‐Chia Wang, Emily Dorsey, Connie Wu
wiley   +2 more sources

Advances in BODIPY Derivatives for Antibacterial Phototherapy

open access: yesAngewandte Chemie, EarlyView.
This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv   +9 more
wiley   +2 more sources

Home - About - Disclaimer - Privacy