Results 91 to 100 of about 7,757 (261)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Generalized Newton’s method for solving nonlinear and nondifferentiable algebraic systems

Journal of Numerical Analysis and Approximation Theory, 2015
In this paper a model based on non-smooth equations is proposed for solving a non-linear and non-differential equation obtained by discretization of a quasi-variational inequality that models the frictional contact problem. The main aim of this paper is
Nicolae Pop
doaj   +2 more sources

A Novel Approach to Energy Management in Electric Steelworks

steel research international, EarlyView.
Feed‐forward neural networks are exploited to estimate electric energy consumptions of the electric arc furnace and ladle furnace processes. The models are used to optimize production schedule so that more energy intensive grades are produced when the cost of energy is lower.
Valentina Colla, Stefano Dettori, Silvia Cateni, Marco Vannucci, Antonella Vignali, Claudio Mocci, Irene Dovichi, Davide Chionna, Lorenzo Vannini, Enrico Paluzzano, Costanzo Pietrosanti, Davide Onesti, Daniele Venier   +12 more
wiley   +1 more source

A Family of Newton and Quasi-Newton Methods for Power Flow Analysis in Bipolar Direct Current Networks with Constant Power Loads

Mathematical and Computational Applications
This paper presents a comprehensive study on the formulation and solution of the power flow problem in bipolar direct current (DC) distribution networks with unbalanced constant power loads.
Oscar Danilo Montoya, Juan Diego Pulgarín Rivera, Luis Fernando Grisales-Noreña, Walter Gil-González, Fabio Andrade-Rengifo   +4 more
doaj   +1 more source

Agglomeration Behavior of Nonmetallic Particles on the Surface of Si‐Killed Liquid Steel Using HT‐CSLM: An In Situ Investigation

steel research international, EarlyView.
The in situ agglomeration behavior of semisolid Al–silicate inclusions in Si‐killed steel is studied using high‐temperature confocal scanning laser microscopy. Particle motion and interparticle forces at the steel/argon interface are quantified and compared with a modified capillary interaction model.
Suwam Kumar, Muhammad Nabeel, Angshuman Podder, Andre B. Phillion, Neslihan Dogan   +4 more
wiley   +1 more source

Efficiency and Stability of a New Hybrid Unconstrained Optimization Algorithm with Quasi-Newton Updates and Higher-Order Methods

Mathematics
We propose the higher-order quasi-Newton (HOQN) method, a hybrid algorithm for unconstrained optimization that combines Newtonian predictors with higher-order correctors derived from vector extensions of the Traub, Chun, and Ostrowski methods, along with
Alicia Cordero, Javier G. Maimó, Juan R. Torregrosa, Natanael Ureña Castillo   +3 more
doaj   +1 more source

Sensitivity study on accuracy and relevant parameters in numerical modeling of internal tendon breaks

Structural Concrete, EarlyView.
Abstract This study investigates the numerical modeling of internal tendon breaks in prestressed concrete structures and evaluates the key parameters affecting accuracy. A combined approach is followed, involving global sensitivity analysis via the Elementary Effects Method and subsequent model calibration using experimental data from distributed fiber‐
Aeneas Paul, David Sanio, Peter Mark
wiley   +1 more source

Pre‐task Vocabulary Support Enhances Lexical Learning but Dampens Positive Emotions: Interactive Task Implementation in English‐as‐a‐Foreign‐Language Classroom

TESOL Quarterly, EarlyView.
Abstract This classroom study explored the effects of vocabulary support on collocation learning and affective responses in task‐based language teaching (TBLT) among English‐as‐a‐foreign‐language (EFL) learners at a Japanese university. For this purpose, 68 EFL learners completed two interactive information‐gap tasks under either vocabulary‐support or ...
Yuichi Suzuki, Sachiko Nakamura
wiley   +1 more source

An Effective Space-Borne ISAR High-Resolution Imaging Approach for Satellite On-Orbit Based on Minimum Entropy Optimization

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The space situational awareness program places great significance on obtaining high-resolution images of satellite in space orbit. By utilizing space-borne inverse synthetic aperture radar (SBISAR) can achieve high-resolution imaging of observed ...
Yifei Liu, Weidong Yu, Shenghui Yang, Shiqiang Li   +3 more
doaj   +1 more source

Estimating crippling loss from hunting with multistate models: a case study on northern bobwhites

Wildlife Biology, EarlyView.
Hunting as a recreational pursuit provides an important ecosystem service worldwide. Harvest management plays a vital role in regulating wildlife take to ensure long‐term population sustainability and meet value‐based objectives (e.g. hunter satisfaction). However, managers rarely have complete control or observability of harvest mortality.
Amanda S. Cramer, Justin A. Rectenwald, William B. Lewis, Michael A. Hazelbaker, Alexander L. Jackson, Holly K. Lott, Geoff Beane, D. Clay Sisson, Melanie R. Kunkel, Nicole M. Nemeth, James A. Martin   +10 more
wiley   +1 more source