When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert +6 more
wiley +1 more source
Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary +5 more
wiley +1 more source
Combining quasi-one-dimensional modeling with region-wise structure analysis for rapid technology computer-aided design simulations of gate-all-around MOSFETs. [PDF]
Lee KW +4 more
europepmc +1 more source
Oxygen Attachment Dissociation of Protonated Reserpine and Its Analogs
ABSTRACT Rationale Carbon–carbon double bonds are ubiquitous structural motifs in natural products and pose a key challenge in locating their presence in analytes via MS‐based methods. Here, we use the alkaloid reserpine as a model system to examine whether OAD reactions can locate quaternary double bonds embedded in fused multicyclic structures ...
Jack G. Li +5 more
wiley +1 more source
Freeze-and-Release Direct Optimization Method for Variational Calculations of Excited Electronic States. [PDF]
Schmerwitz YLA, Selenius E, Levi G.
europepmc +1 more source
Nonlinear Model Order Reduction on Polynomial Manifolds for Computational Homogenisation Problems
ABSTRACT Model order reduction (MOR) techniques utilising nonlinear approximation spaces can search for solutions to computational homogenisation problems on low‐dimensional approximation spaces. In combination with hyperreduction techniques, this allows for computations on representative volume elements (RVEs) to be accelerated by multiple orders of ...
Erik Faust, Lisa Scheunemann
wiley +1 more source
Nonlinear Schwarz Preconditioning for Quasi-Newton Methods
We propose the nonlinear restricted additive Schwarz (RAS) preconditioning strategy to improve the convergence speed of limited memory quasi-Newton (QN) methods. We consider both "left-preconditioning" and "right-preconditioning" strategies. As the application of the nonlinear preconditioning changes the standard gradients and Hessians to their ...
openaire +2 more sources
Experimental methods in chemical engineering: Atomic absorption spectrometry—AAS
Abstract Elements absorb electromagnetic radiation (light) of a specific wavelength in proportion to the number of atoms in its path. As the atoms absorb this light energy, electrons rise from the ground state to an excited state. In atomic absorption spectrometry (AAS), high temperatures produce clouds of atoms from the sample (atomization) and ...
Emily Cintia Tossi de A. Costa +4 more
wiley +1 more source
Damping factor estimation of damped complex sinusoidal signals using a maximum likelihood approach. [PDF]
Karthikeyan A, Rahul AK, Tiwari R.
europepmc +1 more source
ABSTRACT Aim Self‐assessment is critical in nursing education, enabling students to reflect on their cognitive and clinical skills while helping educators identify gaps in competencies. Combining subjective self‐assessment with the objectivity of Objective Structured Clinical Examinations (OSCEs) supports learning adjustments.
Virginia La Rosa‐Salas +4 more
wiley +1 more source

