When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart
The Journal of Physiology, EarlyView.Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert +6 more
wiley +1 more source
Algebraic evaluation of optimization in tumors classification with numerical assessments via a flask-react web interface. [PDF]
Front Digit HealthHoussa N, Abdelalim S, Elmouki I.
europepmc +1 more source
Nonlinear Schwarz Preconditioning for Quasi-Newton Methods
We propose the nonlinear restricted additive Schwarz (RAS) preconditioning strategy to improve the convergence speed of limited memory quasi-Newton (QN) methods. We consider both "left-preconditioning" and "right-preconditioning" strategies. As the application of the nonlinear preconditioning changes the standard gradients and Hessians to their ...
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary +5 more
wiley +1 more source
A Comparative Study of the Acute Toxicities of Three-Dimensional Conformal Radiotherapy (3D-CRT) Versus Intensity-Modulated Radiotherapy (IMRT) in Locally Advanced and Inoperable Oral Cavity Cancer. [PDF]
CureusRahamat Ullah M +3 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source
On‐Chip Learning With Crossbar Arrays for Adaptive Edge Intelligence
Advanced Computing, Volume 1, Issue 1, December 2026.Memristor crossbar arrays implemented on chip combines memory, computation, and learning. They allow for adapting the neural weights using the incoming sensor data. This architecture reduces data movement leading to low‐latency, energy‐efficient intelligence in edge while being reliability‐aware co‐design across devices, circuits, and algorithms that ...
Alex James
wiley +1 more source
Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.ABSTRACT The previously introduced X‐FFT solver permits solving three‐dimensional linear elastic homogenization problems with high accuracy and efficiency. Due to the extended finite element discretization (X‐FEM), matrix‐inclusion problems may be approximated with the error convergence of interface‐conforming finite elements.
Flavia Gehrig, Matti Schneider
wiley +1 more source
Algorithm selection for lithium-ion battery ECM parameterization: a comparative study of trust-region, Levenberg-Marquardt, Gauss-Newton, and BFGS for accuracy and physical consistency. [PDF]
Sci RepYadav A +7 more
europepmc +1 more source
Study of Liquid Flow Through a Channel With Adjacent Porous Domains of Different Material Properties
Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.ABSTRACT A common subject in engineering disciplines is the study of flow in and around fractures or channels with adjacent porous domains. In this work, a unified approach based on the Theory of Porous Media (TPM) with an embedded Phase‐Field (PF) fracture model is used to investigate a flow scenario, where a channel separates two porous domains with ...
Yann Rivas +5 more
wiley +1 more source