Results 111 to 120 of about 18,939 (195)

Combinatorial analysis and algorithms for quasispecies reconstruction using next-generation sequencing

BMC Bioinformatics, 2011
Background Next-generation sequencing (NGS) offers a unique opportunity for high-throughput genomics and has potential to replace Sanger sequencing in many fields, including de-novo sequencing, re-sequencing, meta-genomics, and characterisation of ...
Vincenti Donatella, Rozera Gabriella, Abbate Isabella, Bruselles Alessandro, Prosperi Luciano, Prosperi Mattia CF, Solmone Maria, Capobianchi Maria, Ulivi Giovanni   +8 more
doaj   +1 more source

Fundamental Properties of the Evolution of Mutational Robustness [PDF]

, 2015
Evolution on neutral networks of genotypes has been found in models to concentrate on genotypes with high mutational robustness, to a degree determined by the topology of the network.
Altenberg, Lee
core  

The relationship between the error catastrophe, survival of the flattest, and natural selection

BMC Evolutionary Biology, 2011
Background The quasispecies model is a general model of evolution that is generally applicable to replication up to high mutation rates. It predicts that at a sufficiently high mutation rate, quasispecies with higher mutational robustness can displace ...
Montero Francisco, Marín Arturo, Tejero Héctor   +2 more
doaj   +1 more source

Quasispecies characteristics of hepatitis B virus full genome in Tibetans studied by the third-generation sequencing

Di-san junyi daxue xuebao, 2019
Objective To investigate the quasispecies variation characteristics of HBV in Tibetan population based on the third-generation sequencing. Methods An epidemiological investigation of hepatitis B virus was conducted by our department of infectious disease
CAI Lin, CAI Lin, ZHENG Junfeng, TAN Wenting, SUN Fengming   +4 more
doaj   +1 more source

Mutation, Quasispecies, and Lethal Mutagenesis

, 2014
Viral pathogenesis is not alien to the evolutionary history of a virus. Picornaviruses, simply by the fact of sharing a phylogenetic position, need not be associated with similar diseases, reflecting that the nature of the interactions with their host organisms may depend in a subtle manner on minimal genetic change of the virus.
Domingo, Esteban, Perales, Celia, Agudo, Rubén, Arias, Armando, Escarmís, Cristina, Ferrer-Orta, Cristina, Verdaguer, Núria   +6 more
openaire   +2 more sources

The quasispecies distribution

, 2016
The quasispecies model was introduced in 1971 by Manfred Eigen to discuss the first stages of life on Earth. It provides an appealing mathematical framework to study the evolution of populations in biology, for instance viruses. We present briefly the model and we focus on its stationary solutions.
Cerf, Raphaël, Dalmau, Joseba
openaire   +2 more sources

Quasispecies and Pre-Existing Drug-Resistant Mutations of Hepatitis B Virus in Patients with Chronic Hepatitis B

Gut and Liver, 2013
Background/AimsTo investigate pre-existing hepatitis B virus (HBV) quasispecies and the genotypic evolution of several variants.Methods : From six patients with lamivudine (LAM) failure, serum samples at pretreatment, 6 months of LAM therapy, and ...
doaj   +1 more source

Feasibility of using 454 pyrosequencing for studying quasispecies of the whole dengue viral genome

BMC Genomics, 2012
Background Dengue is the world's most common mosquito-borne viral disease. Poor proofreading by RNA polymerase during its replication results in the accumulation of mutations in its genome.
Chin-inmanu Kwanrutai, Suttitheptumrong Aroonroong, Sangsrakru Duangjai, Tangphatsornruang Sithichoke, Tragoonrung Somvong, Malasit Prida, Tungpradabkul Sumalee, Suriyaphol Prapat   +7 more
doaj   +1 more source

Quasispecies of genotype 4 of hepatitis C virus genomes in Saudi patients managed with interferon alfa and ribavirin therapy

Annals of Saudi Medicine, 2010
Background and Objectives : Many patients with hepatitis C virus (HCV) infection do not respond to antiviral treatment, possibly due to viral quasispecies.
Al-Qahtani Ahmed, Kessie George, Cruz Damian, Al-Faleh Faleh, Al-Ahdal Mohammed   +4 more
doaj  

Variations and evolution of HIV-1 provirus in peripheral blood under the pressure of ART. [PDF]

Virus Evol
Liang Y, Deng H, Li Q, Zhang C, Li J, Kong Q, Zou Z, Li L, Chen W.   +8 more
europepmc   +1 more source