Results 101 to 110 of about 18,939 (195)
Population Bottlenecks in Quasispecies Dynamics
, 2006 The characteristics of natural populations result from different stochastic and deterministic processes that include reproduction with error, selection, and genetic drift. In particular, population fluctuations constitute a stochastic process that may play a very relevant role in shaping the structure of populations.
Escarmís, Cristina +2 more
openaire +3 more sources
Virus Quasispecies Rarefaction: Subsampling with or without Replacement?
VirusesIn quasispecies diversity studies, the comparison of two samples of varying sizes is a common necessity. However, the sensitivity of certain diversity indices to sample size variations poses a challenge.
Josep Gregori +4 more
doaj +1 more source
Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]
, 2010 One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core
Journal of Neurochemistry, Volume 169, Issue 3, March 2025.The normal prion protein (PrPC) fold is shared among mammals; however, it can undergo misfolding in various ways, giving rise to distinct infectious prion (PrPSc) strains. This review describes independent misfolding subdomains within PrP, recognised through new structural alignments and comparisons with the novel deer chronic wasting disease (CWD ...
Szymon W. Manka
wiley +1 more source
Natural Resistance to HIV Infection: Role of Immune Activation
Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.High and low immune activation have been proposed as a possible explanation in HIV‐1 resistance. This review focuses on the most relevant evidence supporting each perspective. ABSTRACT Introduction Although repeated exposure to HIV‐1 can result in infection, some individuals remain seronegative without clinical or serologic evidence of infection; these
María M. Naranjo‐Covo +4 more
wiley +1 more source
Finite-size scaling of the error threshold transition in finite population
, 1998 The error threshold transition in a stochastic (i.e. finite population) version of the quasispecies model of molecular evolution is studied using finite-size scaling.
Binder K +15 more
core +1 more source
Error threshold in simple landscapes
, 1996 We consider the quasispecies description of a population evolving in both the "master sequence" landscape (where a single sequence is evolutionarily preferred over all others) and the REM landscape (where the fitness of different sequences is an ...
Dietrich S +9 more
core +1 more source
Virology Journal, 2005 Much of the worlds' population is in active or imminent danger from established infectious pathogens, while sporadic and pandemic infections by these and emerging agents threaten everyone. RNA polymerases (RNApol) generate enormous genetic and consequent
Sallie Richard
doaj +1 more source
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System
, 2006 Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies.
A. K. Abbas +3 more
core +1 more source
Viruses as Quasispecies: Biological Implications [PDF]
, 2006 During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. Mutant spectra are continuously and avoidably generated during RNA genome replication, and they are not just a by-product of error-prone
Domingo, E. +5 more
openaire +2 more sources