Results 91 to 100 of about 18,939 (195)
Journal of Medical Virology, Volume 97, Issue 7, July 2025.ABSTRACT SARS‐CoV‐2 has evolved from early variants dominating the first (B.1.5, B.1.1) and second (B.1.177) pandemic waves, which exhibited a higher frequency of minority mutants with deletions leading to Defective Viral Genomes (DVGs) in the spike region near the S1/S2 cleavage site than the Alpha, Beta, and Delta variants.
Carolina Campos +23 more
wiley +1 more source
Norovirus Polymerase Fidelity Contributes to Viral Transmission
mSphere, 2016 Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias +4 more
doaj +1 more source
Adaptation dynamics of the quasispecies model
, 2008 We study the adaptation dynamics of an initially maladapted population evolving via the elementary processes of mutation and selection. The evolution occurs on rugged fitness landscapes which are defined on the multi-dimensional genotypic space and have ...
C. Darwin +9 more
core +1 more source
Hepatitis B Virus Variants and Cytokine Patterns in Acute Liver Failure and Transplant‐Free Survival
Liver International, Volume 45, Issue 7, July 2025.ABSTRACT Background & Aims Only 25% of hepatitis B‐related acute liver failure (HBV‐ALF) patients survive without liver transplantation (transplant‐free survival, TFS). There is limited study of immunological and virological profiles in these patients.
Nishi H. Patel +48 more
wiley +1 more source
Favipiravir elicits antiviral mutagenesis during virus replication in vivo
eLife, 2014 Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral infections. Several studies have demonstrated that increases in the high mutation rates inherent to RNA viruses lead to viral extinction in cell culture, but evidence
Armando Arias +2 more
doaj +1 more source
Tropical Medicine and Health, 2011 Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role in chronic infectious diseases, but little is known about their involvement in acute infectious diseases such as ...
openaire +3 more sources
Quasispecies dynamics with network constraints
Journal of Theoretical Biology, 2012 A quasispecies is a set of interrelated genotypes that have reached a situation of equilibrium while evolving according to the usual Darwinian principles of selection and mutation. Quasispecies studies invariably assume that it is possible for any genotype to mutate into any other, but recent finds indicate that this assumption is not necessarily true.
Barbosa, Valmir C. +2 more
openaire +3 more sources
RNA Virus Populations as Quasispecies [PDF]
, 1992 RNA virus mutation frequencies generally approach maximum tolerable levels, and create complex indeterminate quasispecies populations in infected hosts. This usually favors extreme rates of evolution, although periods of relative stasis or equilibrium, punctuated by rapid change may also occur (as for other life forms).
J J, Holland +2 more
openaire +2 more sources
Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms
Journal of Medical Virology, Volume 97, Issue 5, May 2025.ABSTRACT HIV exhibits significant genetic diversity, with genetic recombination being a major evolutionary process. The co‐circulation of HIV‐1/M and HIV‐1/O variants has led to the description of 20 HIV‐1/M+O dual infections since 1998. Despite the genetic divergence between these variants, HIV‐1/M+O dual infections have resulted in the emergence of ...
Alice Moisan +2 more
wiley +1 more source
Evolutionary dynamics of the most populated genotype on rugged fitness landscapes
, 2007 We consider an asexual population evolving on rugged fitness landscapes which are defined on the multi-dimensional genotypic space and have many local optima.
C. L. Burch +18 more
core +1 more source