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Antiprotozoal activities of quassinoids

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Quassinoids: Phytochemistry and antitumor prospect

Phytochemistry, 2021
Quassinoids, originating from the oxidative degradation of tetracyclic tirucallane triterpene, are a diverse class of secondary metabolites identifying from nature mostly in Simaroubaceae family. The crucial pharmacological activities and structural complexity of quassinoids have long fascinated scientists due to their medicinal uses, infamous toxicity,
Shu-Hui Dong, Yu-Xi Wang, Shao-Jiang Song   +2 more
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Quassinoids from Eurycoma longifolia

Phytochemistry, 2002
Three quassinoids, eurycolactone D (1), eurycolactone E (2) and eurycolactone F (3) were isolated from the roots of Eurycoma longifolia Jack. The structures of 1-3 were elucidated by spectroscopic methods, and that of 3 was further confirmed by X-ray crystallography.
Hooi Hoon Ang, Yukio Hitotsuyanagi, Haruhiko Fukaya   +2 more
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Quassinoids from Ailanthus excelsa

Phytochemistry, 2003
Three quassinoids, 1, 2 and 3, 4-dihydro excelsin 3 were isolated from the stem bark of Ailanthus excelsa, along with five known quassinoids excelsin, glaucarubine, ailanthinone, glaucarubinone and glaucarubolone. The glaucarubolone has been isolated for the first time from this plant.
Ram Prakash Sharma
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Quassinoids from Eurycoma harmandiana

Phytochemistry, 2001
Three quassinoids, iandonosides A and B and iandonone, were isolated from the root of Eurycoma harmandiana, along with five known quassinoids, casteloside B, 13 beta, 21-dihydroeurycomanone, chaparrinone, glaucarubolone and ailanquassin B as well as the coumarin, scopoletin. The structural elucidations were based on analyses of spectroscopic data.
Tripetch Kanchanapoom, Ryoji Kasai
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Cytotoxic quassinoids from Ailanthus altissima

Bioorganic and Medicinal Chemistry Letters, 2013
Two new quassinoids, altissinol A (1) and B (7), together with 12 known quassinoids, were isolated from the 95% ethanol extract of the barks of Ailanthus altissima. The structures of the new compounds (1 and 7) were determined on the basis of the spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR.
Wen-Jing Wang, Dong-Mei Zhang, Rong-Rong He   +2 more
exaly   +3 more sources

Antifeedant activity of quassinoids

Journal of Chemical Ecology, 1984
The antifeedant activity of 13 quassinoids of different structural types has been studied against the Mexican bean beetle (Epilachna varivestis Mulsant) 4th instar larvae and the southern armyworm (Spodoptera eridania Crawer) 5th instar larvae. All quassinoids tested displayed significant activity against the Mexican bean beetle and, thus, do not ...
V, Leskinen, J, Polonsky, S, Bhatnagar
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Quassinoids from Picrasma Crenata

Natural Product Research, 2003
From woods of Picrasma crenata, a new stereoisomer dihydronorneoquassin was obtained together with others well knowns dihydronorneoquassin, parain, alpha-neoquassin, beta-neoquassin and quassin. The structures were determined by spectroscopic data and chemical evidence.
Claudio R, Novello, Antonio G, Ferreira, Luis C, Marques, Diógenes A G, Cortez   +3 more
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Synthesis of cytotoxic fluorinated quassinoids

Bioorganic & Medicinal Chemistry, 1997
The C-15 senecioyl side chain of brusatol was interchanged with fluorinated acyl groups, and the C-3 hydroxy group of bruceolide was esterified with fluorinated acyl chlorides. These fluorinated quassinoids 11, 12, 13, and 17 showed significant cytotoxic activity against eight human cancer cell lines including small and non-small cell lung, colon, CNS,
N, Ohno, N, Fukamiya, M, Okano, K, Tagahara, K H, Lee   +4 more
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Synthetic studies in the quassinoid series. Conversion of chaparrin into castelanone and quassinoid analogs.

Tetrahedron Letters, 1982
Abstract Inactive chaparrin 1 has been converted in seven steps and in 16% overall yield to castelanone 3 which is known to inhibit significantly growth of the murine lymphocytic leukemia P-388 cell line. The methodology developed has been applied to the preparation of quassinoid analogs 15 , 16 and 17 .
Andrew J. Caruso, Judith Poplonsky, Bertha Soto Rodriguez   +2 more
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