Results 131 to 140 of about 557 (166)

Anti-HIV activity of quassinoids

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C ( 20 ) demonstrated the highest anti-HIV activity (EC 50 = 10.6 μM) in the absence of cytotoxicity with a therapeutic index of >25.
Masayoshi Okano, Narihiko Fukamiya, Kiyoshi Tagahara, Mark Cosentino, Thomas Tung-Ying Lee, Susan Morris-Natschke, Kuo-Hsiung Lee   +6 more
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A quassinoid from Brucea javanica

Phytochemistry, 1990
Abstract The structure for javanicin, a novel quassinoid isolated from Brucea javanica , was determined by a combination of spectral X-ray crystallographic analyses.
Long-Ze Lin, Geoffrey A. Cordell, Chao-Zhou Ni, Jon Clardy   +3 more
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Quassinoids as Promising Anti-cancer Agents

Current Medicinal Chemistry
The use of current anticancer drugs is hampered by significant side effects and high costs. In the pursuit of safer, more effective, and affordable options, researchers have turned to nature as a valuable source of potential anticancer compounds. Quassinoids, a class of natural terpenoids, have garnered attention for their anticancer properties. This
Tripti Mishra, null Saima, Bimal Krishna Banik   +2 more
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Quassinoids from Ailanthus vilmoriniana

Phytochemistry, 1998
Five new quassinoids, named vilmorinines B-F, have been isolated from the cortex of Ailanthus vilmoriniana. Their structures were established by various spectroscopic methods.
Koichi Takeya, Hideyuki Kobata, Akira Ozeki, Hiroshi Morita, Hideji Itokawa   +4 more
openaire   +1 more source

Chemogeographical evolution of quassinoids in simaroubaceae

Phytochemistry, 1991
Abstract The presence of canthinones and β-carbolines suggests the derivation of the Simaroubaceae from protorutaceous stock. The evolutionary trend towards the substitution of such anthranilate-derived alkaloids by limonoids in Rutaceae is paralleled by their substitution by quassinoids in Simaroubaceae.
Sheila M. Simão, Euclides L. Barreiros, M.Fátima das G.F. Da Silva, Otto R. Gottlieb   +3 more
openaire   +1 more source

Quassinoids from Aeschrion crenata

Phytochemistry, 1972
Abstract From the bark of Aeschrion crenata Vell. (sin. Picrasma crenata (Vell.) Engl., Simaroubaceae) three new quassinoids, paraine (II), isoparaine (III), and 12-norquassine (IV), have been isolated. The last two compounds are already known as transformation products of other quassinoids.
J.C. Vitagliano, J. Comin
exaly   +2 more sources

Biologically active quassinoids : synthetic methodology for the conversion of chaparrin into glaucarubolone esters and quassinoid analogs

Tetrahedron, 1987
Abstract Biologically inactive but easily available chaparrin 2a has been converted into potent antileukemic C-15 esters of glaucarubolone 2b and quassinoid analogs in which the C-15 ester side chain has been replaced by an alkyl or alkenyl group.The synthetic methodology developed has been applied to the preparation of C-15 ester ...
Subodh C. Bhatnagar, Andrew J. Caruso, Judith Polonsky, Berta Soto Rodriguez   +3 more
openaire   +1 more source

Evolution of quassinoids and limonoids in the rutales

Biochemical Systematics and Ecology, 1987
Abstract The structural types of quassinoids and limonoids can be characterized in terms of complexity according to their skeletal specialization and state of oxidation. The analysis of such dynamic parameters in the quassinoid-limonoid group of families in the Rutales indicates that the Simaroubaceae should form the more primitive taxon, split off ...
M.Fátima Das, G.F. Da Silva, Otto R. Gottlieb   +2 more
openaire   +1 more source

Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids

Bioorganic & Medicinal Chemistry, 2004
Twenty-three quassinoids (1-23), which were isolated previously from Simaroubaceous plants, were evaluated for cytotoxicity against three multidrug-resistant cancer cell lines, KB-VIN, KB-7d, and KB-CPT. Nine compounds (2-7 and 9-11) showed significant cytotoxicity in all three cell lines.
Chihiro, Murakami, Narihiko, Fukamiya, Sadaaki, Tamura, Masayoshi, Okano, Kenneth F, Bastow, Harukuni, Tokuda, Teruo, Mukainaka, Hoyoky, Nishino, Kuo-Hsiung, Lee   +8 more
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Synthetic bicyclic analogues of quassinoids

Tetrahedron, 1998
A series of simple bicyclic analogues of quassinoids have been prepared including compounds with ring A typical of bruceolides and dehydrobruceolides. The synthesis of bicyclic compound 5 and tricyclic analogue 6 was accomplished by acid catalysed Robinson Annelation reaction. Hydroxyketone 9a and its 2-substituted analogues were also prepared to study
Thoruwa, C. L., Watt, Robert A., Toth, Istvan, Phillipson, David J.   +3 more
openaire   +2 more sources