Results 211 to 220 of about 77,067 (300)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Large-scale phenotypic and genomic analysis of <i>Listeria monocytogenes</i> reveals diversity in the sensitivity to quaternary ammonium compounds but not to peracetic acid. [PDF]

Appl Environ Microbiol
Ivanova M, Laage Kragh M, Szarvas J, Tosun ES, Holmud NF, Gmeiner A, Amar C, Guldimann C, Huynh TN, Karpíšková R, Rota C, Gomez D, Aboagye E, Etter A, Centorame P, Torresi M, De Angelis ME, Pomilio F, Okholm AH, Xiao Y, Kleta S, Lüth S, Pietzka A, Kovacevic J, Pagotto F, Rychli K, Zdovc I, Papić B, Heir E, Langsrud S, Møretrø T, Brown P, Kathariou S, Stephan R, Tasara T, Dalgaard P, Njage PMK, Fagerlund A, Aarestrup F, Truelstrup Hansen L, Leekitcharoenphon P.   +40 more
europepmc   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

Bushy-Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution. [PDF]

ChemMedChem
Toles ZEA, Thierer LM, Wu A, Bezold EL, Rachii D, Sanchez CA, Vargas-Cuebas GG, Keller TM, Carroll PJ, Wuest WM, Minbiole KPC.   +10 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Exploring antimicrobial interactions between metal ions and quaternary ammonium compounds toward synergistic metallo-antimicrobial formulations. [PDF]

Microbiol Spectr
Lekhan A, Turner RJ.
europepmc   +1 more source

Functionalized Organic Lithium Salt Enables Flexible Solid‐State Electrolytes With Dual‐Ion Channels for Safe Li Metal Batteries

Carbon Energy, EarlyView.
Here, we design a flexible and non‐flammable solid‐state electrolyte with hierarchical dual‐ion conductive channels. The engineered electrolyte combines continuous organic conductive‐phase pathways for fast bulk Li+ transport and dynamic polymer networks for interfacial ion hopping, achieving unprecedented room temperature conductivity (> 1 mS cm−1 ...
Yijing Liu, Zifan Bu, Han Fang, Xiao Xu, Jinrui Hu, Lixia Bao, Weibo Kong, Jiliang Wang   +7 more
wiley   +1 more source

High‐Energy‐Density Redox Flow Batteries: Mechanisms, Design Strategies, and Recent Progress

Chemistry – A European Journal, EarlyView.
ABSTRACT The inherent intermittency of energy sources such as solar and wind power hinders the transition to renewable energy, necessitating advanced energy storage solutions. Enhancing energy density is crucial for lowering system costs and enabling large‐scale deployment.
Xiaolian Zhao, Jiaxin Yu, Nannan Jia, Chuzhang Hong, Yue Luo, Wantong Jing, Zhiming Feng, Xinhua Liu, Rui Tan   +8 more
wiley   +1 more source

Effect of Sub-Inhibitory Concentrations of Quaternary Ammonium Compounds and Heavy Metals on Antibiotic Resistance and Expression of Virulence Factors Among <i>Staphylococcus</i> spp. from Dairy Products. [PDF]

Int J Mol Sci
Byczkowska-Rostkowska Z, Gajewska J, Zadernowska A, Chajęcka-Wierzchowska W.   +3 more
europepmc   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source