Results 101 to 110 of about 18,101 (260)

Efflux Pump Mediated Streptococcus Mutans Resistance To Quaternary Ammonium Salt

open access: yesInternational Dental Journal
Aim or purpose: The goals of this study were to explore the mechanisms of Streptococcus mutans (S. mutans) resistance to quaternary ammonium salt (QAS), dimethylaminohexadecyl methacrylate (DMAHDM). Materials and methods: Drug-resistance of S.
Yingxiang Chen   +6 more
doaj   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan   +4 more
wiley   +1 more source

Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer. [PDF]

open access: yesGels, 2023
Lin T   +17 more
europepmc   +1 more source

Quaternary ammonium salt containing antibacterial nanofibers

open access: yes, 2021
Different techniques have been used in the preparation of nanoscale structures with a high surface area such as biomaterial scaffolds for vascular grafts, wound dressings or air purifying filters. In the present study, an antibacterial agent, such as cethyltrimethyl ammonium bromide(CTAB) and cetylpyrridinum chloride (CPC) have been incorporated into ...
openaire   +1 more source

Understanding cationic polyelectrolyte thermogels with varying charge densities toward biomaterials design

open access: yesBMEMat, EarlyView.
Cationic polyurethane thermogels with customizable charge density were developed, exhibiting enhanced pH‐responsiveness. This work elucidates how cationic charges influence self‐assembly and thermogelling, providing insights for designing smart biomaterials.
Belynn Sim   +10 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

open access: yesBMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie   +12 more
wiley   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

open access: yesBiotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu   +6 more
wiley   +1 more source

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