Results 61 to 70 of about 39,138 (264)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Automatic Query Expansion based Document Retrieval System using Hyper Tuned Graph Enhanced Bi-directional Encoder Representation from Transformers with Manifold Ranking Algorithm

International Transactions on Electrical Engineering and Computer Science
Document retrieval system automatic query expansion (AQE) adds relevant phrases to user searches to improve search results. AQE enhances recollection but introduces irrelevant phrases, increases computing complexity, and slows retrieval.
D. Y. B. Priyadarshini, S. Aquter Babu
doaj   +1 more source

A Quantum Query Expansion Approach for Session Search

Entropy, 2016
Recently, Quantum Theory (QT) has been employed to advance the theory of Information Retrieval (IR). Various analogies between QT and IR have been established.
Peng Zhang, Jingfei Li, Benyou Wang, Xiaozhao Zhao, Dawei Song, Yuexian Hou, Massimo Melucci   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Semantic Sequential Query Expansion for Biomedical Article Search

IEEE Access, 2018
The conventional sequential dependence model (SDM) has been proved to perform better than the bag of words model for biomedical article search because it pays attention to the sequence information within queries.
Fan Fang, Bo-Wen Zhang, Xu-Cheng Yin
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Taxonomy and Survey of Semantic Approaches for Query Expansion

IEEE Access, 2019
Conventional approaches to query expansion (QE) rely on the integration of an unstructured corpus and probabilistic rules for the extraction of candidate expansion terms.
Muhammad Ahsan Raza, Rahmah Mokhtar, Noraziah Ahmad, Maruf Pasha, Urooj Pasha   +4 more
doaj   +1 more source

Head Concepts Selection for Verbose Medical Queries Expansion

IEEE Access, 2020
Semantic concepts and relations encoded in domain-specific ontologies and other medical semantic resources play a crucial role in deciphering terms in medical queries and documents.
Mohammed Maree, Israa Noor, Khaled S. Rabayah, Mohammed Belkhatir, Saadat M. Alhashmi   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source