Results 71 to 80 of about 1,392,110 (286)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
User - thesaurus interaction in a web-based database : An evaluation of users' term selection behaviour [PDF]
, 2001 A major challenge faced by users during the information search and retrieval process is the selection of search terms for query formulation and expansion.
Shiri, A.A., Revie, C.W.
core +4 more sources
A Quantum Query Expansion Approach for Session Search
Entropy, 2016 Recently, Quantum Theory (QT) has been employed to advance the theory of Information Retrieval (IR). Various analogies between QT and IR have been established.
Peng Zhang +6 more
doaj +1 more source
Document expansion, query translation and language modeling for ad-hoc IR [PDF]
, 2010 For the multilingual ad-hoc document retrieval track (TEL) at CLEF, Trinity College Dublin and Dublin City University participated in collaboration. Our retrieval experiments focused on i) document expansion using an entry vocabulary module, ii) query ...
Wade, Vincent +7 more
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Incorporating user search behaviour into relevance feedback [PDF]
, 2003 In this paper we present five user experiments on incorporating behavioural information into the relevance feedback process. In particular we concentrate on ranking terms for query expansion and selecting new terms to add to the user's query.
van Rijsbergen, C.J. +6 more
core +4 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Patent query reduction using pseudo relevance feedback [PDF]
, 2011 Queries in patent prior art search, being full patent applications, are very much longer than standard ad hoc search and web search topics. Standard information retrieval (IR) techniques are not entirely effective for patent prior art search because of ...
Magdy, Walid +3 more
core +3 more sources
International Transactions on Electrical Engineering and Computer ScienceDocument retrieval system automatic query expansion (AQE) adds relevant phrases to user searches to improve search results. AQE enhances recollection but introduces irrelevant phrases, increases computing complexity, and slows retrieval.
D. Y. B. Priyadarshini, S. Aquter Babu
doaj +1 more source