Results 71 to 80 of about 39,138 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A multi-dimensional semantic pseudo-relevance feedback framework for information retrieval
Scientific ReportsPre-trained models have garnered significant attention in the field of information retrieval, particularly for improving document ranking. Typically, an initial retrieval step using sparse methods such as BM25 is employed to obtain a set of pseudo ...
Min Pan +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Bug Report Reformulation Method Based on Topic Consistency Maintenance and Pseudo-correlation Feedback Library Extension [PDF]
Jisuanji kexueTo enhance the speed of locating software bugs for developers,a set of bug location techniques based on text retrieval has been proposed.These techniques aim to automatically recommend potentially suspicious code files associated with bug reports ...
LIU Wenjie, ZOU Weiqin, CAI Biyu, CHEN Bingting
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Aggregated Deep Local Features for Remote Sensing Image Retrieval
Remote Sensing, 2019 Remote Sensing Image Retrieval remains a challenging topic due to the special nature of Remote Sensing imagery. Such images contain various different semantic objects, which clearly complicates the retrieval task.
Raffaele Imbriaco +3 more
doaj +1 more source
Learning to rank query expansion terms for COVID-19 scholarly search. [PDF]
J Biomed Inform, 2023 Khader A, Ensan F.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
RbQE: An Efficient Method for Content-Based Medical Image Retrieval Based on Query Expansion. [PDF]
J Digit Imaging, 2023 Rashad M, Afifi I, Abdelfatah M.
europepmc +1 more source