Results 71 to 80 of about 1,705,573 (348)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Improving automatic query expansion [PDF]

open access: yesProceedings of the 21st annual international ACM SIGIR conference on Research and development in information retrieval, 1998
Most casual users of IR systems type short queries. Recent research has shown that adding new words to these queries via odhoc feedback improves the retrieval effectiveness of such queries. We investigate ways to improve this query expansion process by refining the set of documents used in feedback. We start by using manually formulated Boolean filters
Amit Singhal   +2 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

A Quantum Query Expansion Approach for Session Search

open access: yesEntropy, 2016
Recently, Quantum Theory (QT) has been employed to advance the theory of Information Retrieval (IR). Various analogies between QT and IR have been established.
Peng Zhang   +6 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Keyword expansion techniques for mining social movement data on social media

open access: yesEPJ Data Science, 2022
Political and social scientists have been relying extensively on keywords such as hashtags to mine social movement data from social media sites, particularly Twitter.
Lia Bozarth, Ceren Budak
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Exploring Query Categorisation for Query Expansion: A Study

open access: yes, 2015
The vocabulary mismatch problem is one of the important challenges facing traditional keyword-based Information Retrieval Systems. The aim of query expansion (QE) is to reduce this query-document mismatch by adding related or synonymous words or phrases to the query.
Pal, Dipasree   +2 more
openaire   +2 more sources

Semantic Sequential Query Expansion for Biomedical Article Search

open access: yesIEEE Access, 2018
The conventional sequential dependence model (SDM) has been proved to perform better than the bag of words model for biomedical article search because it pays attention to the sequence information within queries.
Fan Fang, Bo-Wen Zhang, Xu-Cheng Yin
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

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