Results 51 to 60 of about 198,739 (283)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Towards a query language for annotation graphs [PDF]
, 2000 The multidimensional, heterogeneous, and temporal nature of speech databases raises interesting challenges for representation and query. Recently, annotation graphs have been proposed as a general-purpose representational framework for speech databases ...
Bird, Steven +2 more
core +5 more sources
Proceedings of the 2019 International Conference on Management of Data, 2019 In recent decades, we observed the rapid growth of several big data platforms. Each of them is designed for specific demands. For instance, Spark can efficiently process iterative queries, while Storm is designed for in-memory processing. In this context, the complexity of these distributed systems make it much harder to develop rigorous cost models ...
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Minimization of data base query's conditions: evoluation of efficiency
Труды Института системного программирования РАН, 2018 This paper describes enhanced algorisms of query lexical optimization. These algorisms detect and remove redundant conditions from query restriction to simplify it.
N. A. Mendkovich, S. D. Kuznetsov
doaj
A Cardinality Estimator in Complex Database Systems Based on TreeLSTM
Sensors, 2023 Cardinality estimation is critical for database management systems (DBMSs) to execute query optimization tasks, which can guide the query optimizer in choosing the best execution plan.
Kaiyang Qi, Jiong Yu, Zhenzhen He
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Parametric query optimization [PDF]
The VLDB Journal The International Journal on Very Large Data Bases, 1997 In most database systems, the values of many important run-time parameters of the system, the data, or the query are unknown at query optimization time. Parametric query optimization attempts to identify at compile time several execution plans, each one of which is optimal for a subset of all possible values of the run-time parameters. The goal is that
Yannis E. Ioannidis +3 more
openaire +1 more source