Results 61 to 70 of about 2,049,708 (294)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Information, 2018 Faced with the rapid growth of vector data and the urgent requirement of low-latency query, it has become an important and timely challenge to effectively achieve the scalable storage and efficient access of vector big data.
Hua Jiang +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
IEEE Access, 2023 According to the characteristics of massive, multi-source, heterogeneous, and rapid growth of book literature data information from the perspective of the metaverse, in order to meet the requirements of efficient management and rapid retrieval such as ...
Dailin Wang, Lina Liu, Yali Liu
doaj +1 more source
Classification of index partitions to boost XML query performance [PDF]
, 2010 XML query optimization continues to occupy considerable research effort due to the increasing usage of XML data. Despite many innovations over recent years, XML databases struggle to compete with more traditional database systems. Rather than using node
Marks, Gerard +4 more
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Minimization of data base query's conditions: evoluation of efficiency
Труды Института системного программирования РАН, 2018 This paper describes enhanced algorisms of query lexical optimization. These algorisms detect and remove redundant conditions from query restriction to simplify it.
N. A. Mendkovich, S. D. Kuznetsov
doaj
Efficient Storage and Query Optimization for Large-Scale Data Sets in Distributed Architectures
Advanced ElectromagneticsWith the rapid development of the big data industry, data volume across various industries has exploded, and large-scale datasets at PB and EB levels have become mainstream objects for data processing. Relying on core theories of distributed storage and
Y. G. Zhao
doaj +1 more source
Heterogeneous Fusion Storage Blockchain Query Optimization Approach for Business Environment Evaluation [PDF]
Jisuanji kexue yu tansuoThe strategic implications of the business environment??s strengths and limitations are pivotal for advancing high-quality, sustainable growth in modern economies.
LI Su, WANG Junlu, CHEN Ze, WANG Yan, SONG Baoyan
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source