Results 81 to 90 of about 2,049,708 (294)

Query Optimization in Distributed Database Based on Improved Artificial Bee Colony Algorithm

open access: yesApplied Sciences
Query optimization is one of the key factors affecting the performance of database systems that aim to enact the query execution plan with minimum cost. Particularly in distributed database systems, due to the multiple copies of the data that are stored ...
Yan Du, Zhi Cai, Zhiming Ding
doaj   +1 more source

Ontological queries: Rewriting and optimization

open access: yes2011 IEEE 27th International Conference on Data Engineering, 2011
Ontological queries are evaluated against an enterprise ontology rather than directly on a database. The evaluation and optimization of such queries is an intriguing new problem for database research. In this paper we discuss two important aspects of this problem: query rewriting and query optimization. Query rewriting consists of the compilation of an
Georg Gottlob   +2 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Index ordering by query-independent measures [PDF]

open access: yes, 2012
Conventional approaches to information retrieval search through all applicable entries in an inverted file for a particular collection in order to find those documents with the highest scores. For particularly large collections this may be extremely time
Smeaton, Alan F., Ferguson, Paul
core   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Optimization of Queries Containing Conjunctions of Conditions

open access: yesМоделирование и анализ информационных систем, 2011
A new algorithm for query optimization is proposed. This algorithm simplifies queries restriction containing multi-attribute conditions. It also solves the problem of "Condition AND Conjunction of conditions" expressions.
S. D. Kuznetsov, N. A. Mendkovich
doaj  

The SPARQL Query Graph Model for Query Optimization [PDF]

open access: yes, 2007
The Semantic Web community has proposed several query languages for RDF before the World Wide Web Consortium started to standardize SPARQL. Due to the declarative nature of the query language, a query engine should be responsible to choose an efficient evaluation strategy.
Olaf Hartig, Ralf Heese
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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