Results 61 to 70 of about 198,739 (283)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Query Optimization in Distributed Database Based on Improved Artificial Bee Colony Algorithm

open access: yesApplied Sciences
Query optimization is one of the key factors affecting the performance of database systems that aim to enact the query execution plan with minimum cost. Particularly in distributed database systems, due to the multiple copies of the data that are stored ...
Yan Du, Zhi Cai, Zhiming Ding
doaj   +1 more source

Optimizing navigational graph queries

open access: yesThe VLDB Journal
Abstract We study the optimization of navigational graph queries in the form of the Regular Queries, i.e., queries which combine recursive and pattern-matching fragments. Current approaches to their evaluation are not effective in practice.
Thomas Mulder   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

SMOQE: A System for Providing Secure Access to XML [PDF]

open access: yes, 2006
XML views have been widely used to enforce access control, support data integration, and speed up query answering. In many applications, e.g., XML security enforcement, it is prohibitively expensive to materialize and maintain a large number of views ...
Fan, Wenfei   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Distributed Query Optimization by Query Trading

open access: yes, 2004
Large-scale distributed environments, where each node is completely autonomous and offers services to its peers through external communication, pose significant challenges to query processing and optimization. Autonomy is the main source of the problem, as it results in lack of knowledge about any particular node with respect to the information it can ...
Fragkiskos Pentaris, Yannis Ioannidis
openaire   +3 more sources

New algorithms for query modifications

open access: yesМоделирование и анализ информационных систем, 2009
New algorithms for query modifications are proposed. These algorithms involve the lexical optimization based on the mathematical transformations that have never been used for the query optimization before.
S. D. Kuznetsov, N. A. Mendkovich
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

SQL UŽKLAUSŲ OPTIMIZAVIMO TYRIMAS = SQL QUERY OPTIMIZATION RESEARCH

open access: yesTaikomieji tyrimai studijose ir praktikoje, 2017
Although scientific literature studies different aspects of SQL query optimization the major part of researches is limited to the theoretical analysis of problems.
Jurgita Lieponienė
doaj  

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