Results 71 to 80 of about 4,751,671 (372)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Query Rewriting and Optimization for Ontological Databases [PDF]

TODS, 2014
Ontological queries are evaluated against a knowledge base consisting of an extensional database and an ontology (i.e., a set of logical assertions and constraints that derive new intensional knowledge from the extensional database), rather than directly
G. Gottlob, G. Orsi, Andreas Pieris
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Minimization of data base query's conditions: evoluation of efficiency

Труды Института системного программирования РАН, 2018
This paper describes enhanced algorisms of query lexical optimization. These algorisms detect and remove redundant conditions from query restriction to simplify it.
N. A. Mendkovich, S. D. Kuznetsov
doaj  

Normalized Storage Model Construction and Query Optimization of Book Multi-Source Heterogeneous Massive Data

IEEE Access, 2023
According to the characteristics of massive, multi-source, heterogeneous, and rapid growth of book literature data information from the perspective of the metaverse, in order to meet the requirements of efficient management and rapid retrieval such as ...
Dailin Wang, Lina Liu, Yali Liu
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

SMOQE: A System for Providing Secure Access to XML [PDF]

, 2006
XML views have been widely used to enforce access control, support data integration, and speed up query answering. In many applications, e.g., XML security enforcement, it is prohibitively expensive to materialize and maintain a large number of views ...
Fan, Wenfei, Geerts, Floris, Jia, Xibei, Kementsietsidis, Anastasios   +3 more
core   +1 more source

Query Optimization in Distributed Database Based on Improved Artificial Bee Colony Algorithm

Applied Sciences
Query optimization is one of the key factors affecting the performance of database systems that aim to enact the query execution plan with minimum cost. Particularly in distributed database systems, due to the multiple copies of the data that are stored ...
Yan Du, Zhi Cai, Zhiming Ding
doaj   +1 more source