Results 71 to 80 of about 193,669 (327)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Foundations of SPARQL query optimization

Proceedings of the 13th International Conference on Database Theory, 2010
The SPARQL query language is a recent W3C standard for processing RDF data, a format that has been developed to encode information in a machine-readable way. We investigate the foundations of SPARQL query optimization and (a) provide novel complexity results for the SPARQL evaluation problem, showing that the main source of complexity is operator ...
Georg Lausen, Michael Schmidt, Michael Meier   +2 more
openaire   +4 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Query Complexity of Derivative-Free Optimization [PDF]

, 2012
This paper provides lower bounds on the convergence rate of Derivative Free Optimization (DFO) with noisy function evaluations, exposing a fundamental and unavoidable gap between the performance of algorithms with access to gradients and those with ...
Jamieson, Kevin G., Nowak, Robert D., Recht, Benjamin   +2 more
core   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Optimization of Queries Containing Conjunctions of Conditions

Моделирование и анализ информационных систем, 2011
A new algorithm for query optimization is proposed. This algorithm simplifies queries restriction containing multi-attribute conditions. It also solves the problem of "Condition AND Conjunction of conditions" expressions.
S. D. Kuznetsov, N. A. Mendkovich
doaj  

Cache Pattern with Multi-Queries

Advances in Electrical and Computer Engineering, 2010
This article proposes a cache pattern with multi-queries and describes the multi-query optimization with scheduling, caching and pipelining. A set of cache patterns is derived from a set of class of multi-queries that are loaded into the cache.
TUDOR, N. L.
doaj   +1 more source

Learning Tuple Probabilities [PDF]

, 2016
Learning the parameters of complex probabilistic-relational models from labeled training data is a standard technique in machine learning, which has been intensively studied in the subfield of Statistical Relational Learning (SRL), but---so far---this is
Dylla, Maximilian, Theobald, Martin
core   +1 more source

Query Optimization for Ontology-Mediated Query Answering

Proceedings of the ACM Web Conference 2024
Ontology-mediated query answering (OMQA) consists in asking database queries on knowledge bases (KBs); a KB is a set of facts called the KB's database, which is described by domain knowledge called the KB's ontology. A widely-investigated OMQA technique is FO-rewriting: every query asked on a KB is reformulated w.r.t.
Wafaa El Husseini, Cheikh Brahim El Vaigh, François Goasdoué, Hélène Jaudoin   +3 more
openaire   +2 more sources