Results 81 to 90 of about 4,751,671 (372)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Research on Temporal Query Expansion and Temporal Index Optimization Based on Spark [PDF]
Jisuanji gongcheng, 2017 There exists some temporal databases and temporal analysis tools based on cluster-based computing systems.However,most of them are disk-oriented and performance degenerate rapidly when processing big data.This paper proposes a system which is based on ...
ZHOU Liang,LI Gefei,TAI Weipeng,ZHENG Xiao
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Convex Optimization for Linear Query Processing under Approximate Differential Privacy
, 2016 Differential privacy enables organizations to collect accurate aggregates over sensitive data with strong, rigorous guarantees on individuals' privacy. Previous work has found that under differential privacy, computing multiple correlated aggregates as a
Hao, Zhifeng +3 more
core +1 more source
New algorithms for query modifications
Моделирование и анализ информационных систем, 2009 New algorithms for query modifications are proposed. These algorithms involve the lexical optimization based on the mathematical transformations that have never been used for the query optimization before.
S. D. Kuznetsov, N. A. Mendkovich
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
SQL UŽKLAUSŲ OPTIMIZAVIMO TYRIMAS = SQL QUERY OPTIMIZATION RESEARCH
Taikomieji tyrimai studijose ir praktikoje, 2017 Although scientific literature studies different aspects of SQL query optimization the major part of researches is limited to the theoretical analysis of problems.
Jurgita Lieponienė
doaj
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
Distributed Query Optimization by Query Trading
, 2004 Large-scale distributed environments, where each node is completely autonomous and offers services to its peers through external communication, pose significant challenges to query processing and optimization. Autonomy is the main source of the problem, as it results in lack of knowledge about any particular node with respect to the information it can ...
Fragkiskos Pentaris, Yannis Ioannidis
openaire +3 more sources
Query Complexity of Derivative-Free Optimization [PDF]
, 2012 This paper provides lower bounds on the convergence rate of Derivative Free Optimization (DFO) with noisy function evaluations, exposing a fundamental and unavoidable gap between the performance of algorithms with access to gradients and those with ...
Jamieson, Kevin G. +2 more
core +1 more source