Results 81 to 90 of about 480,811 (337)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Query Expansion Based on Clustered Results [PDF]

Proceedings of the VLDB Endowment (PVLDB), Vol. 4, No. 6, pp. 350-361 (2011), 2011
Query expansion is a functionality of search engines that suggests a set of related queries for a user-issued keyword query. Typical corpus-driven keyword query expansion approaches return popular words in the results as expanded queries. Using these approaches, the expanded queries may correspond to a subset of possible query semantics, and thus miss ...
arxiv  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Cache Pattern with Multi-Queries

Advances in Electrical and Computer Engineering, 2010
This article proposes a cache pattern with multi-queries and describes the multi-query optimization with scheduling, caching and pipelining. A set of cache patterns is derived from a set of class of multi-queries that are loaded into the cache.
TUDOR, N. L.
doaj   +1 more source

A Novel Urban Emergency Path Planning Method Based on Vector Grid Map

IEEE Access, 2020
When an emergency occurs in the city, a large area of road congestion usually occurs. Therefore, it is particularly important to provide an effective emergency path planning strategy for vehicles.
Bowen Yang, Zhiming Ding, Lei Yuan, Jin Yan, Limin Guo, Zhi Cai   +5 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Optimization of Queries Containing Conjunctions of Conditions

Моделирование и анализ информационных систем, 2011
A new algorithm for query optimization is proposed. This algorithm simplifies queries restriction containing multi-attribute conditions. It also solves the problem of "Condition AND Conjunction of conditions" expressions.
S. D. Kuznetsov, N. A. Mendkovich
doaj  

Ontological Queries: Rewriting and Optimization (Extended Version) [PDF]

arXiv, 2011
Ontological queries are evaluated against an ontology rather than directly on a database. The evaluation and optimization of such queries is an intriguing new problem for database research. In this paper we discuss two important aspects of this problem: query rewriting and query optimization.
arxiv  

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

One Size Does Not Fit All: Querying Web Polystores

IEEE Access, 2019
Data retrieval systems are facing a paradigm shift due to the proliferation of specialized data storage engines (SQL, NoSQL, Column Stores, MapReduce, Data Stream, and Graph) supported by varied data models (CSV, JSON, RDB, RDF, and XML).
Yasar Khan, Antoine Zimmermann, Alokkumar Jha, Vijay Gadepally, Mathieu D'Aquin, Ratnesh Sahay   +5 more
doaj   +1 more source