Results 91 to 100 of about 470,015 (281)
Flexible query processing of SPARQL queries [PDF]
, 2018 SPARQL is the predominant language for querying RDF data, which is the standard model for representing web data and more specifically Linked Open Data (a collection of heterogeneous connected data). Datasets in RDF form can be hard to query by a user if she does not have a full knowledge of the structure of the dataset.
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Retracted: Location-Dependent Query Processing: Semantic Cache for Real-Time Smart City Analytics. [PDF]
Appl Bionics Biomech, 2023 And Biomechanics AB.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Graph processing engine based on graph query system
大数据, 2019 Recently,graph query and graph processing are emphasis of graph-structured data research.However,independent graph system mismatched combining applications,which needed both query and processing.To avoid some issues brought by independent system,such as ...
Xuehan KE, Rong CHEN
doaj
GeoSpark SQL: An Effective Framework Enabling Spatial Queries on Spark
ISPRS International Journal of Geo-Information, 2017 In the era of big data, Internet-based geospatial information services such as various LBS apps are deployed everywhere, followed by an increasing number of queries against the massive spatial data.
Zhou Huang +3 more
doaj +1 more source
A Unified Approach to Spatial Proximity Query Processing in Dynamic Spatial Networks. [PDF]
Sensors (Basel), 2021 Cho HJ.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source