Results 81 to 90 of about 102,125 (260)

Optimizing Skyline Query Processing in Incomplete Data

open access: yesIEEE Access, 2019
Given the significance of skyline queries, they are incorporated in various modern applications including personalized recommendation systems as well as decision-making and decision-support systems.
Yonis Gulzar   +2 more
doaj   +1 more source

Hydro: Adaptive Query Processing of ML Queries

open access: yesCoRR
Query optimization in relational database management systems (DBMSs) is critical for fast query processing. The query optimizer relies on precise selectivity and cost estimates to effectively optimize queries prior to execution. While this strategy is effective for relational DBMSs, it is not sufficient for DBMSs tailored for processing machine ...
Gaurav Tarlok Kakkar   +4 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Graph processing engine based on graph query system

open access: yes大数据, 2019
Recently,graph query and graph processing are emphasis of graph-structured data research.However,independent graph system mismatched combining applications,which needed both query and processing.To avoid some issues brought by independent system,such as ...
Xuehan KE, Rong CHEN
doaj  

GeoSpark SQL: An Effective Framework Enabling Spatial Queries on Spark

open access: yesISPRS International Journal of Geo-Information, 2017
In the era of big data, Internet-based geospatial information services such as various LBS apps are deployed everywhere, followed by an increasing number of queries against the massive spatial data.
Zhou Huang   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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