Results 91 to 100 of about 3,172,290 (290)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Survey on AI Powered New Techniques for Query Processing and Optimization
Jisuanji kexue yu tansuo, 2020 As one of the most challenging problems in data management, query processing and optimization are always widely concerned by researchers. However, it is very difficult for traditional techniques to meet the diverse requirements of modern database system ...
SONG Yumeng, GU Yu, LI Fangfang, YU Ge
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Smart Intra-query Fault Tolerance for Massive Parallel Processing Databases
Data Science and Engineering, 2019 Intra-query fault tolerance has increasingly been a concern for online analytical processing, as more and more enterprises migrate data analytical systems from mainframes to commodity computers.
Yunhong Ji +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Probabilistic CkNN Queries of Uncertain Data in Large Road Networks
IEEE Access, 2016 Continuous k-nearest neighbor (CkNN) query processing is an important issue in spatial temporal databases. In real-world scenarios, query clients and data objects may move with uncertain speeds on the road networks, which makes retrieving the exact CkNN ...
Yanhong Li +4 more
doaj +1 more source
ANEW TECHNIQUE BY USING INVERTED TABLES AND 3D BOX FOR EFFICIENT QUERYING OVER AN ENCRYPTED DATABASE
Iraqi Journal for Computers and Informatics, 2020 The increase in the amount of data in encrypted databases has caused problems in data processing and retrieval time. In traditional query processing methods, there are many difficulties in execute query over an encrypted database because it is time ...
Atheer Metaab Al Abbassi +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Process Instance Query Language and the Process Querying Framework
, 2022 Junta de Andalucía US-1381375 (METAMORFOSIS)
Pérez Álvarez, José Miguel +5 more
openaire +3 more sources