Results 101 to 110 of about 1,560,042 (297)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Construction and Evaluation of Intelligent Question Answering System for Electric Power Knowledge Base Based on Large Language Model [PDF]

open access: yesJisuanji kexue
Large language model is a major breakthrough in the field of natural language processing in recent years and have become a new paradigm for research in this field.In vertical fields such as finance and law,intelligent question and answering systems based
ZHANG Jinying, WANG Tiankun, YAO Changying, XIE Hua, CHAI Linzheng, LIU Shukai, LI Tongliang, LI Zhoujun
doaj   +1 more source

CRQA: Crowd-Powered Real-Time Automatic Question Answering System

open access: yesAAAI Conference on Human Computation & Crowdsourcing, 2016
Modern search engines have made dramatic progress in answering questions about facts, such as those that might be retrieved or directly inferred from a knowledge base.
Denis Savenkov, Eugene Agichtein
semanticscholar   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Marie and BERT-A Knowledge Graph Embedding Based Question Answering System for Chemistry. [PDF]

open access: yesACS Omega, 2023
Zhou X   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

MoReVQA: Exploring Modular Reasoning Models for Video Question Answering [PDF]

open access: yesComputer Vision and Pattern Recognition
This paper addresses the task of video question answering (videoQA) via a decomposed multi-stage, modular rea-soning framework. Previous modular methods have shown promise with a single planning stage ungrounded in visual content.
Juhong Min   +4 more
semanticscholar   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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