Results 71 to 80 of about 5,616,767 (291)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Public, non-public : questions de méthodologie

, 2017
Centre de recherche sur les médiations Communication, langue, art, culture (EA 3476, Université de Lorraine, France) ¿ Interrogations ?, 24, 2017 Public, non-public : questions de ...
Angeliki Koukoutsaki-Monnier
core   +1 more source

Thanks to the CHIVA strategy, may the histoarchitecture of great saphenous vein-sparing, make it suitable as graft for bypasses?

Veins and Lymphatics, 2019
Not ...
Roberto Delfrate
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Philosophy of Medicine; 5 Questions

, 2011
Philosophy of Medicine: 5 Questions is a collection of short interviews based on five provoking questions presented to some of the most influential and prominent scholars in field.
Nordenfelt, Lennart,
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

An evaluation of pedagogically informed parameterised questions for self assessment [PDF]

, 2008
Self-assessment is a crucial component of learning. Learners can learn by asking themselves questions and attempting to answer them. However, creating effective questions is time-consuming because it may require considerable resources and the skill of ...
Davis, Hugh, Gilbert, Lester, Sitthisak, Onjira   +2 more
core   +1 more source

Rhetorical questions, relevance and scales

, 1998
Rhetorical questions, and other varieties of pragmatically conditioned questions, present a challenge for a purely truth-conditional theory of the interpretation of interrogatives.
Gutiérrez Rexach, Javier
core   +1 more source

INSTITUTIONS ET POLITIQUES DANS LES PAYS EMERGENTS : UNE LECTURE INSTITUTIONNALISTE COMPAREE

Regard lucide
Cet article explore les interactions entre institutions et politiques économiques dans le contexte des pays dits émergents. À travers une comparaison approfondie du Brésil, du Vietnam, de l’Afrique du Sud et du Maroc, il montre que les trajectoires d ...
Augustin KUPA MUKADI
doaj  

Physical Intelligence and Thermodynamic Computing

Entropy, 2017
This paper proposes that intelligent processes can be completely explained by thermodynamic principles. They can equally be described by information-theoretic principles that, from the standpoint of the required optimizations, are functionally equivalent.
Robert L. Fry
doaj   +1 more source