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Aims: To estimate the prevalence of self-reported misuse of the antipsychotic quetiapine fumarate (quetiapine) among a sample of urban Australian people who inject drugs (PWID), and correlates of reported misuse in health and social domains.
Raimondo Bruno +2 more
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Dosing and switching strategies for quetiapine fumarate
Clinical Therapeutics, 2002The atypical antipsychotic agent quetiapine fumarate has demonstrated efficacy and tolerability in clinical trials in patients with chronic or subchronic exacerbations of schizophrenic symptoms.This review summarizes clinical trial data and other practical information regarding the initiation and routine administration of quetiapine.
Andrew J, Cutler +2 more
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Identification and Characterization of Potential Impurities of Quetiapine Fumarate
Pharmaceutical Development and Technology, 2008Seven potential impurities, including by-products, starting materials and intermediates were identified in pharmaceutical substance quetiapine fumarate and characterized by spectroscopic methods (MS, IR, NMR). Based on these methods the structures of the impurities were assigned or confirmed as: impurity I: 2-(phenylthio)aniline; impurity II: phenyl N-[
Elzbieta U, Stolarczyk +5 more
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Identification, isolation, synthesis and characterization of impurities of quetiapine fumarate
Die Pharmazie, 2008In the process for the preparation of quetiapine fumarate (1), six unknown impurities and one known impurity (intermediate) were identified ranging from 0.05–0.15% by reverse-phase HPLC. These impurities were isolated from crude samples using reverse-phase preparative HPLC. Based on the spectral data, the impurities were characterized as 2-[4-dibenzo[b,
Ch, Bharathi +7 more
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009
This 10-day, single-center, open-label, randomized, crossover study compared pharmacokinetic profiles and tolerability of extended release quetiapine fumarate (quetiapine XR) with quetiapine immediate release (quetiapine IR) in patients with schizophrenia, schizoaffective disorder or bipolar disorder.
Carlos, Figueroa +3 more
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This 10-day, single-center, open-label, randomized, crossover study compared pharmacokinetic profiles and tolerability of extended release quetiapine fumarate (quetiapine XR) with quetiapine immediate release (quetiapine IR) in patients with schizophrenia, schizoaffective disorder or bipolar disorder.
Carlos, Figueroa +3 more
openaire +2 more sources
: Objective The objective of this study was to assess the safety and tolerability of extended-release quetiapine fumarate (quetiapine XR) compared with quetiapine immediate-release (quetiapine IR) in older patients with Alzheimer's disease with symptoms ...
Peter Paul De Deyn, Hans Eriksson
exaly +1 more source
Current Medical Research and Opinion, 2013
A series of studies were conducted to guide the development and characterise the pharmacokinetics of extended-release quetiapine fumarate (quetiapine XR), a once-daily formulation to control the release of the drug.Data from these studies are described and discussed herein.Once-daily quetiapine XR produced a similar area under the plasma concentration ...
Khanh, Bui +2 more
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A series of studies were conducted to guide the development and characterise the pharmacokinetics of extended-release quetiapine fumarate (quetiapine XR), a once-daily formulation to control the release of the drug.Data from these studies are described and discussed herein.Once-daily quetiapine XR produced a similar area under the plasma concentration ...
Khanh, Bui +2 more
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Quetiapine fumarate (Seroquel(R)): A new atypical antipsychotic
Drugs of Today, 1999The goal of antipsychotic drug development efforts over the past 10 years has been to develop agents with increased efficacy and safety and fewer of the side effects commonly associated with the older antipsychotic medications. The newer agents, often called atypical antipsychotics, are effective in treating both the positive and negative symptoms of ...
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Quetiapine fumarate overdose: Clinical and pharmacokinetic lessons from extreme conditions
Clinical Pharmacology & Therapeutics, 2000Although the new atypical antipsychotic, quetiapine fumarate, is growing in popularity over its progenitor, clozapine, clinical experience with overdose of this agent remains limited. Observation of an overdose situation provided a unique opportunity to define the safety, clinical effects, and pharmacokinetics of this medication more clearly.A patient ...
P T, Pollak, K, Zbuk
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Pharmacokinetics, Tolerability, and Clinical Effectiveness of Quetiapine Fumarate
The Journal of Clinical Psychiatry, 2000This is the first investigation of the pharmacokinetics, tolerability, and efficacy of quetiapine fumarate in adolescents with chronic or intermittent psychotic disorders.Ten patients with DSM-IV chronic or intermittent psychotic disorders (ages 12.3 through 15.9 years) participated in an open-label, rising-dose trial and received oral doses of ...
B J, McConville +10 more
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