“One-Pot” CuCl2-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine [PDF]
Molecules, 2022 The efficient “One-pot” CuCl2-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2 ...
Dehe Wang +6 more
doaj +7 more sources
Dibenzothiazepine Based MCR Chemistry [PDF]
European Journal of Organic Chemistry, 2022 AbstractPrivileged scaffolds which can unveil unknown territories of the chemical space are constantly prominent. As such, 1,5‐dibenzothiazepines not only offer structural diversification but also a very unique binding mode due to their “butterfly” conformation.
Giasemi K Angeli +2 more
exaly +5 more sources
Footprinting of Inhibitor Interactions of In Silico Identified Inhibitors of Trypanothione Reductase of Leishmania Parasite [PDF]
The Scientific World Journal, 2012 Structure-based virtual screening of NCI Diversity set II compounds was performed to indentify novel inhibitor scaffolds of trypanothione reductase (TR) from Leishmania infantum. The top 50 ranked hits were clustered using the AuPoSOM tool.
Santhosh K. Venkatesan +1 more
doaj +3 more sources
NOVEL DIBENZOTHIAZEPINES WITHOUT SUBSTITUTION ON THE SULFONAMIDE GROUP [PDF]
Synthetic Communications, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Nicolas Lebègue +2 more
exaly +3 more sources
Etude Electrochimique et Differenciation de Derives des Dibenzodiazepines et des Dibenzothiazepines [PDF]
Analytical Letters, 1978 Abstract New psychotropic drugs like Clozapin and Clothiapin were separated and differenciated using D.C., A.C. and D.P.P. polarographic techniques. The mechanism of the electrode reaction is elucidated.
G J Patriarche
exaly +5 more sources
Organocatalyzed Annulation Cascade toward Asymmetric Functionalization of Dibenzoxazepines and Dibenzothiazepines with Vicinal Tertiary Stereogenic Centers [PDF]
ChemistrySelect, 2019 Abstract An efficient organocatalyzed annulation cascade has been established for the stereoselective functionalization of dibenzoxazepine and dibenzothiazepine scaffolds. The protocol used ready‐stock proline as a catalyst and a variety biologically important oxa/thiazepine based polycyclic frameworks featuring congested chiral ...
Isai Ramakrishna, Mahiuddin Baidya
exaly +3 more sources
ChemInform Abstract: Synthesis of Nitrated Benzo‐ and Dibenzothiazepines as Antiparasitics. [PDF]
ChemInform, 1988 D. BESANTY +5 more
openaire +2 more sources
Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain
Pharmaceuticals, 2022 Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or diseases of the somatosensory nervous system. Many drugs are available but unfortunately do not provide satisfactory effects in patients, producing limited analgesia and undesirable side effects.
Young-Hwan Jung +13 more
openaire +3 more sources
Λειτουργικά μόρια μέσω αντιδράσεων πολλών συστατικών: εφαρμογές στην φαρμακευτική χημεία και χημεία υλικών [PDF]
, 2023 Multicomponent reactions (MCRs) are highly efficient one-pot synthetic approaches for the synthesis of complex and versatile scaffolds. To date, these reactions are considered pillars of medicinal and organic chemistry. Surprisingly, their application in
Lei, Xiaofang, Λέι, Ζαοφάνγκ
core +1 more source
Synthesis and Evaluation of Dibenzothiazepines: A Novel Class of Selective Cannabinoid-1 Receptor Inverse Agonists [PDF]
, 2016 A novel class of CB1 inverse agonists was discovered. To efficiently establish structure−activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed.
Jacob Jensen (2381419) +16 more
core +3 more sources