Results 1 to 10 of about 325 (123)

“One-Pot” CuCl₂-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine [PDF]

Molecules, 2022
The efficient “One-pot” CuCl2-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2 ...
Dehe Wang, Qichao Lu, Zhanjun Li, Chen Fang, Ran Liu, Bingchuan Yang, Guodong Shen   +6 more
doaj   +6 more sources

Dibenzothiazepine Based MCR Chemistry [PDF]

European Journal of Organic Chemistry, 2022
Privileged scaffolds which can unveil unknown territories of the chemical space are constantly prominent. As such, 1,5-dibenzothiazepines not only offer structural diversification but also a very unique binding mode due to their “butterfly” conformation.
Giasemi K Angeli, Alexander Dömling, Constantinos G Neochoritis   +2 more
exaly   +5 more sources

Etude Electrochimique et Differenciation de Derives des Dibenzodiazepines et des Dibenzothiazepines [PDF]

Analytical Letters, 1978
New psychotropic drugs like Clozapin and Clothiapin were separated and differenciated using D.C. A.C. and D.P.P. polarographic techniques. The mechanism of the electrode reaction is elucidated. © 1978, Taylor & Francis Group, LLC.
J C Viré, G J Patriarche
exaly   +4 more sources

Footprinting of Inhibitor Interactions of In Silico Identified Inhibitors of Trypanothione Reductase of Leishmania Parasite [PDF]

The Scientific World Journal, 2012
Structure-based virtual screening of NCI Diversity set II compounds was performed to indentify novel inhibitor scaffolds of trypanothione reductase (TR) from Leishmania infantum. The top 50 ranked hits were clustered using the AuPoSOM tool.
Santhosh K. Venkatesan, Vikash Kumar Dubey   +1 more
doaj   +2 more sources

Effectiveness of antipsychotic drug therapy for treating psychosis in people with epilepsy: A systematic review [PDF]

Epilepsia
Individuals with epilepsy are at risk of developing preictal, ictal, postictal and interictal psychoses. Antipsychotic drugs (APDs) are the main class of drugs used to treat psychosis and schizophrenia.
Arora, Aryan, Blackman, Graham, David, Anthony S, Prakash, Priya, Rizzo, Laura, Rogers, Jonathan P   +5 more
core   +5 more sources

Clotiapine for acute psychotic illnesses [PDF]

The Cochrane Library, 2004
Background: Acute psychotic illnesses, especially when associated with agitated or violent behaviour, require urgent pharmacological tranquillisation or sedation.
Michael Berk, John Rathbone
exaly   +3 more sources

Novel Dibenzothiazepines Without Substitution on the Sulfonamide Group.

Synthetic Communications, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lebegue
core   +2 more sources

Synthesis and Evaluation of Dibenzothiazepines: A Novel Class of Selective Cannabinoid-1 Receptor Inverse Agonists

Journal of Medicinal Chemistry, 2009
A novel class of CB1 inverse agonists was discovered. To efficiently establish structure-activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed. The compounds were evaluated in a mammalian cell-based functional assay and in radioligand binding assays expressing recombinant human cannabinoid receptors ...
Burstein E. S., Cheng Y., Compton D. R., Dutta A. K., Hurst D., Jonas Boström J., Lagerlund O., Lange J. H. M., Lange J. H. M., Liljefors T., Lin L. S., Nadin A., Ottesen L. K., Reggio P. H., Rinaldi-Carmona M., Rowley M., Wassvik C. M., Weiner D. M.   +17 more
core   +3 more sources

Organocatalyzed Annulation Cascade toward Asymmetric Functionalization of Dibenzoxazepines and Dibenzothiazepines with Vicinal Tertiary Stereogenic Centers

ChemistrySelect, 2019
Abstract An efficient organocatalyzed annulation cascade has been established for the stereoselective functionalization of dibenzoxazepine and dibenzothiazepine scaffolds. The protocol used ready‐stock proline as a catalyst and a variety biologically important oxa/thiazepine based polycyclic frameworks featuring congested chiral ...
Guo R.-N., Qi H., Zhang C.
core   +2 more sources

STUDIES IN THE HETEROCYCLIC SERIES. XIV. THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF NEW AZA- AND THIA-PHENOTHIAZINES, AND RELATED DIBENZOTHIAZEPINES

Phosphorous and Sulfur and the Related Elements, 1978
Abstract Owing to increasing demand for phenothiazine compounds both in medicine and industry, novel rings in these series have been prepared and evaluated. The benzene rings have been replaced with pyrrole, pyrazole, pyridine, pyridazine, pyrimidine, pyrazine, thiazine and triazine rings or their combinations leading to twelve new polyaza- and thia ...
Aki O., Bovet D., Camerino B., Campbell F. L., Cardellini M., Carelli V., Carelli V., Carelli V., Catsoulacos P., Charpentier P., Dahlbom R., Friend D. G., Harwood P. D., Hift St., Itai T., Ito I., Kaufmann H. P., Kiprianov A. I., Kuraishi T., Kuraishi T., Maki Y., Maki Y., Murphy C. M., Okafor C. O., Okafor C. O., Okafor C. O., Palamidessi G., Selivanova A. S., Shvedov V. I., Tanaka S., Tanaka S., West H. L., Yanai M.   +32 more
core   +2 more sources