Results 11 to 20 of about 342 (137)

Synthesis of the 1,5-Benzothiazepane Scaffold - Established Methods and New Developments. [PDF]

ChemistryOpen, 2023
The 1,5‐benzothiazepane system can be recognized as a key structure in many pharmaceutical agents. It is considered a privileged scaffold as it displays diverse biological activities, and it is easily accessible. This review discusses established protocols as well as new, sustainable developments toward the synthesis of this heterocyclic framework and ...
Ronse U, Magdalenić K, Van Camp J, D'hooghe M.   +3 more
europepmc   +2 more sources

Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain

Pharmaceuticals, 2022
Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or diseases of the somatosensory nervous system. Many drugs are available but unfortunately do not provide satisfactory effects in patients, producing limited analgesia and undesirable side effects.
Young-Hwan Jung, Yeo Ok Kim, Koon Mook Kang, Hyung Gon Lee, Borum Son, Xuehao Han, Eunseok Oh, Siwon Kim, Seon Hee Seo, Jong-Hyun Park, Ki Duk Park, Woong Mo Kim, Myung Ha Yoon, Yong-Chul Kim   +13 more
openaire   +3 more sources

ChemInform Abstract: Synthesis of Nitrated Benzo- and Dibenzothiazepines as Antiparasitics.

ChemInform, 1988
BESANTY
core   +2 more sources

Successful treatment of severe quetiapine intoxication with CytoSorb hemoadsorption

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 9, Page 1471-1474, September 2022., 2022
Plasma quetiapine and norquetiapine levels during the course of Continuous Veno Venous Hemodialysis (CVVHD) + 2 hemoadsorption treatments over 40 h. Note that the pre‐adsorber inlet levels (black triangles) simultaneously represent systemic levels and therefore the overall decrease in plasma levels.
Caterina Reuchsel, Falk A. Gonnert
wiley   +1 more source

Effects of the combination of second‐generation antipsychotics on serum concentrations of aripiprazole and dehydroaripiprazole in Chinese patients with schizophrenia

General Psychiatry, Volume 34, Issue 2, April 2021., 2021
Background Aripiprazole (ARI) is often prescribed alone or in combination with other second‐generation antipsychotics (SGAs) to treat patients with schizophrenia. However, this may increase the potential clinical significance of drug–drug interactions.
Ping Jiang, Xiujia Sun, Juanjuan Ren, Hongmei Liu, Zhiguang Lin, Junwen Liu, Xinyu Fang, Chen Zhang   +7 more
wiley   +1 more source

Unsymmetrically Substituted Dibenzo[b,f][1,5]-diazocine-6,12(5H,11H)dione—A Convenient Scaffold for Bioactive Molecule Design [PDF]

, 2020
A novel approach for the synthesis of unsymmetrically substituted dibenzo[b,f][1,5]diazocine-6,12(5H,11H)diones has been developed. This facile three-step method uses variously substituted 1H-benzo[d][1,3]oxazine-2,4-diones (isatoic anhydrides) and 2 ...
Bieszczad, Bartosz, Garbicz, Damian, Grzesiuk, Elzbieta, Mieczkowski, Adam, Mielecki, Damian, Trzybiński, Damian, Woźniak, Krzysztof   +6 more
core   +1 more source

Electrochemical Oxidation of Derivatives of Dibenzodiazepin. Dibenzothiazepin and Dibenzoxazepin

Analytical Letters, 1979
Abstract Clozapin exhibits two anodic waves at ≥ 1 M H2SO4, but at lower acidities only the first two-electron wave remains. Cyclic voltammetry shows an ECE mechanism. Reversibility decreases at ≥ 10−4 M concentrations, due to formation of an adsorptiob film. In nonaqueous solvents two irreversible one-electron waves appear.
Kauffmann, Jean-Michel, Christian, Gary D., Patriarche, Gaston   +2 more
openaire   +2 more sources

Quetiapine and Wolff‐Parkinson‐White Syndrome

Case Reports in Psychiatry, Volume 2020, Issue 1, 2020., 2020
Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff ...
Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis, Alfredo Bellon, Erik J nsson   +6 more
wiley   +1 more source

Clozapine combined with different antipsychotic drugs for treatment resistant schizophrenia [PDF]

, 2017
Background Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels. For these people, a number of treatment strategies have emerged, including the prescription of a second anti ...
Barber, Sarah, Cipriani, Andrea, Corsi, Martina, Olotu, Uwaila   +3 more
core   +5 more sources

Characterizing the mechanism of quetiapine distribution in lipid-core nanocapsules pseudo-phases using a validated LC/UV method [PDF]

, 2015
Quetiapine is an atypical antipsychotic used to treat schizophrenia. However, despite great interest for its chronic therapeutic use, quetiapine has some important side effects such as weight gain induction.
Carreño, Fernando, Dalla Costa, Teresa Cristina Tavares, Guterres, Silvia Stanisçuaski, Paese, Karina, Silva, Carolina de Miranda   +4 more
core   +3 more sources