Results 11 to 20 of about 312 (115)

Synthesis of the 1,5-Benzothiazepane Scaffold - Established Methods and New Developments. [PDF]

ChemistryOpen, 2023
The 1,5‐benzothiazepane system can be recognized as a key structure in many pharmaceutical agents. It is considered a privileged scaffold as it displays diverse biological activities, and it is easily accessible. This review discusses established protocols as well as new, sustainable developments toward the synthesis of this heterocyclic framework and ...
Ronse U, Magdalenić K, Van Camp J, D'hooghe M.   +3 more
europepmc   +2 more sources

Effectiveness of antipsychotic drug therapy for treating psychosis in people with epilepsy: A systematic review. [PDF]

Epilepsia
Abstract Individuals with epilepsy are at risk of developing preictal, ictal, postictal and interictal psychoses. Antipsychotic drugs (APDs) are the main class of drugs used to treat psychosis and schizophrenia. The efficacy and safety of APDs as a treatment for epileptic psychosis is not well understood.
Arora A, Prakash P, Rizzo L, Blackman G, David AS, Rogers JP.   +5 more
europepmc   +2 more sources

Successful treatment of severe quetiapine intoxication with CytoSorb hemoadsorption

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 9, Page 1471-1474, September 2022., 2022
Plasma quetiapine and norquetiapine levels during the course of Continuous Veno Venous Hemodialysis (CVVHD) + 2 hemoadsorption treatments over 40 h. Note that the pre‐adsorber inlet levels (black triangles) simultaneously represent systemic levels and therefore the overall decrease in plasma levels.
Caterina Reuchsel, Falk A. Gonnert
wiley   +1 more source

Effects of the combination of second‐generation antipsychotics on serum concentrations of aripiprazole and dehydroaripiprazole in Chinese patients with schizophrenia

General Psychiatry, Volume 34, Issue 2, April 2021., 2021
Background Aripiprazole (ARI) is often prescribed alone or in combination with other second‐generation antipsychotics (SGAs) to treat patients with schizophrenia. However, this may increase the potential clinical significance of drug–drug interactions.
Ping Jiang, Xiujia Sun, Juanjuan Ren, Hongmei Liu, Zhiguang Lin, Junwen Liu, Xinyu Fang, Chen Zhang   +7 more
wiley   +1 more source

Electrochemical Oxidation of Derivatives of Dibenzodiazepin. Dibenzothiazepin and Dibenzoxazepin

Analytical Letters, 1979
Abstract Clozapin exhibits two anodic waves at ≥ 1 M H2SO4, but at lower acidities only the first two-electron wave remains. Cyclic voltammetry shows an ECE mechanism. Reversibility decreases at ≥ 10−4 M concentrations, due to formation of an adsorptiob film. In nonaqueous solvents two irreversible one-electron waves appear.
Kauffmann, Jean-Michel, Christian, Gary D., Patriarche, Gaston   +2 more
openaire   +2 more sources

Ligand-Controlled Chemoselective One-Pot Synthesis of Dibenzothiazepinones and Dibenzoxazepinones via Twice Copper-Catalyzed Cross-Coupling [PDF]

, 2017
A highly efficient and generally applicable protocol, starting from 2-bromobenzamides and 2-bromo(thio)phenols via twice copper-catalyzed couplings to afford dibenzothiazepines and dibenzoxazepinones has been developed.
Jian Hu, Xianhua Pan, Yijun Zhou, Rong Zhang, Lanting Xu, Qiujun Peng, Yanyu Chen   +6 more
core   +1 more source

Quetiapine and Wolff‐Parkinson‐White Syndrome

Case Reports in Psychiatry, Volume 2020, Issue 1, 2020., 2020
Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff ...
Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis, Alfredo Bellon, Erik J nsson   +6 more
wiley   +1 more source

Λειτουργικά μόρια μέσω αντιδράσεων πολλών συστατικών: εφαρμογές στην φαρμακευτική χημεία και χημείας υλικών [PDF]

, 2023
Στο πρώτο κεφάλαιο της διατριβής συντέθηκαν για πρώτη φορά 2-τετραζολο ινδόλια μέσω της αντίδρασης UT-4CR, τα οποία αποτελούν βιοϊσοστερή των 2- καρβοξυ ινδολίων. Πραγματοποιήθηκαν επιπλέον MCRs και διάφορες δευτερογενείς συνθετικές μετατροπές.
Lie, Xiaofang J.
core  

Management of Psychosis in Parkinson’s Disease: Emphasizing Clinical Subtypes and Pathophysiological Mechanisms of the Condition

Parkinson's Disease, Volume 2017, Issue 1, 2017., 2017
Investigation into neuropsychiatric symptoms in Parkinson’s disease (PD) is sparse and current drug development is mainly focused on the motor aspect of PD. The tight association of psychosis with an impaired quality of life in PD, together with an important underreporting of this comorbid condition, contributes to its actual insufficient assessment ...
Raquel N. Taddei, Seyda Cankaya, Sandeep Dhaliwal, K. Ray Chaudhuri, Giovanni Mirabella   +4 more
wiley   +1 more source

Freeze Dried Quetiapine‐Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

Journal of Pharmaceutics, Volume 2016, Issue 1, 2016., 2016
Improving the physicochemical properties and oral bioavailability of quetiapine fumarate (QF) enabling enhanced antipsychotic attributes are the main aims of this research. The freeze dried solid dispersion strategy was adopted using nicotinamide (NIC) as highly soluble coformer.
Ahmed Mahmoud Abdelhaleem Ali, Mayyas Mohammad Ahmad Al-Remawi, Sanyog Jain   +2 more
wiley   +1 more source