Results 21 to 30 of about 312 (115)

Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Quetiapine is an atypical antipsychotic, used clinically in the treatment of schizophrenia, acute mania in bipolar disorders, and bipolar depression in adults. In this study, the effect of green tea extracts (GTE) on the pharmacokinetics of quetiapine (substrate of CYP3A4) was investigated in rats.
Essam Ezzeldin, Yousif A. Asiri, Muzaffar Iqbal, Alvin J. Beitz   +3 more
wiley   +1 more source

Development and Validation of a GC‐MS Method for the Detection and Quantification of Clotiapine in Blood and Urine Specimens and Application to a Postmortem Case

International Journal of Analytical Chemistry, Volume 2015, Issue 1, 2015., 2015
Introduction. Clotiapine is an atypical antipsychotic of the dibenzothiazepine class introduced in a few European countries since 1970, efficient in treatment‐resistant schizophrenic patients. There is little published data on the therapeutic and toxic concentrations of this drug. Aims.
Giulio Mannocchi, Flaminia Pantano, Roberta Tittarelli, Miriam Catanese, Federica Umani Ronchi, Francesco Paolo Busardò, Haopeng Wang   +6 more
wiley   +1 more source

Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse‐Phase HPLC with Internal Standard Method

Journal of Chemistry, Volume 2013, Issue 1, 2013., 2013
A rapid, specific, and accurate isocratic HPLC method was developed and validated for the assay of quetiapine fumarate in pharmaceutical dosage forms. The assay involved an isocratic‐elution of quetiapine fumarate in Grace C18 column using mobile‐phase composition of 0.1% ortho phosphoric acid with triethyl amine as modifier buffer and acetonitrile in ...
Kiran B. Venkata, Sreenivas Rao Battula, Somshankar Dubey, Daryoush Afzali   +3 more
wiley   +1 more source

A Rapid and Selective LC‐MS/MS Method for Quantification of Quetiapine in Human Plasma and its Application to Pharmacokinetic Study on Indian Schizophrenia Patients

Journal of Chemistry, Volume 8, Issue 4, Page 1802-1814, 2011., 2011
A rapid, robust and selective high pressure liquid chromatography–positive electrospray ionization tandem mass spectrometry method has been developed and validated for the quantification of quetiapine (QUE) in human plasma with K2EDTA using oxcarbazepine (IS) as an internal standard.
S. Ravinder, A. T. Bapuji, K. Mukkanti, M. Nagesh, H. L. V. Ravikiran   +4 more
wiley   +1 more source

A Validated RP‐HPLC Method for the Estimation of Quetiapine in Bulk and Pharmaceutical Formulations

Journal of Chemistry, Volume 7, Issue S1, Page S261-S266, 2010., 2010
A new, simple, specific, sensitive, rapid, accurate and precise RP‐HPLC method was developed for the estimation of quetiapine in bulk and pharmaceutical formulations. Quetiapine was chromatographed on a reverse phase C18 Waters column (75x4.6 mm I.D., particle size 3.5 μm) in a mobile phase consisting of phosphate buffer (pH 3.0 adjusted with ...
D. Suneetha, A. Lakshmana Rao
wiley   +1 more source

Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine

British Journal of Clinical Pharmacology, Volume 90, Issue 11, Page 2793-2801, November 2024.
Aims: Metamizole is quite an old drug with analgesic, antipyretic and spasmolytic properties. Recent findings have shown that it may induce several cytochrome P450 (CYP) enzymes, especially CYP3A4 and CYP2B6. The clinical relevance of these properties is uncertain.
Fabian Watermeyer, Arnim Johannes Gaebler, Irene Neuner, Ekkehard Haen, Christoph Hiemke, Georgios Schoretsanitis, Michael Paulzen   +6 more
wiley   +1 more source

Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects

Case Reports in Medicine, Volume 2009, Issue 1, 2009., 2009
Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QTc‐prolongation, somnolence, and hyperglycemia.
C. Müller, H. Reuter, C. Dohmen, Rade B. Vukmir   +3 more
wiley   +1 more source

Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe

European Journal of Organic Chemistry, Volume 27, Issue 37, October 1, 2024.
We utilized cyclic N‐sulfonyl ketimines, a privileged class of heterocycles with extensive applications in organic and medicinal chemistry, in four distinct IMCRs, aiming to generate compound libraries compatible for structural elaboration. Four scaffolds, 15 novel compounds with high diversity and complexity, along with single crystal structures for ...
Michael Fragkiadakis, Eirini Fotopoulou, Konstantinos G. Froudas, Constantinos G. Neochoritis   +3 more
wiley   +1 more source

Trajectories of sentiment in 11,816 psychoactive narratives

Human Psychopharmacology: Clinical and Experimental, Volume 39, Issue 1, January 2024.
Abstract Objective Can machine learning (ML) enable data‐driven discovery of how changes in sentiment correlate with different psychoactive experiences? We investigate by training models directly on text testimonials from a diverse 52‐drug pharmacopeia. Methods Using large language models (i.e.
Sam Freesun Friedman, Galen Ballentine
wiley   +1 more source

Synthesis of dibenzothiazepine analogues by one-pot S -arylation and intramolecular cyclization of diaryl sulfides and evaluation of antibacterial properties

Heterocyclic Communications, 2018
Abstract Dibenzothiazepine analogues containing lactam, amidine and imine moieties were prepared from 2-aminophenyl disulfides via one-pot S -arylation. The S -arylation involved cleavage of an S-
Yasutaka Shimotori, Masayuki Hoshi, Mari Murata, Narihito Ogawa, Tetsuo Miyakoshi, Taisei Kanamoto   +5 more
openaire   +1 more source