Results 31 to 40 of about 342 (137)
Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine
British Journal of Clinical Pharmacology, Volume 90, Issue 11, Page 2793-2801, November 2024.Aims: Metamizole is quite an old drug with analgesic, antipyretic and spasmolytic properties. Recent findings have shown that it may induce several cytochrome P450 (CYP) enzymes, especially CYP3A4 and CYP2B6. The clinical relevance of these properties is uncertain.
Fabian Watermeyer +6 more
wiley +1 more source
Case Reports in Medicine, Volume 2009, Issue 1, 2009., 2009 Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QTc‐prolongation, somnolence, and hyperglycemia.
C. Müller +3 more
wiley +1 more source
Unraveling the Potential of Cyclic N‐Sulfonyl Ketimines in the MCR Universe
European Journal of Organic Chemistry, Volume 27, Issue 37, October 1, 2024.We utilized cyclic N‐sulfonyl ketimines, a privileged class of heterocycles with extensive applications in organic and medicinal chemistry, in four distinct IMCRs, aiming to generate compound libraries compatible for structural elaboration. Four scaffolds, 15 novel compounds with high diversity and complexity, along with single crystal structures for ...
Michael Fragkiadakis +3 more
wiley +1 more source
Trajectories of sentiment in 11,816 psychoactive narratives
Human Psychopharmacology: Clinical and Experimental, Volume 39, Issue 1, January 2024.Abstract Objective Can machine learning (ML) enable data‐driven discovery of how changes in sentiment correlate with different psychoactive experiences? We investigate by training models directly on text testimonials from a diverse 52‐drug pharmacopeia. Methods Using large language models (i.e.
Sam Freesun Friedman, Galen Ballentine
wiley +1 more source
Cu/Fe-Catalyzed C-C, C-N and C-S Cross-Coupling Reactions: Synthesis of Biologically Important Heterocycles [PDF]
, 2013 Cross-coupling reactions are an important methodology for the formation of various types of carbon-carbon and carbon-heteroatom bonds. Now a days these reactions are applied in a variety of synthetic venues starting from total synthesis of natural and ...
Jena, A K
core
Clozapine: A special case of an atypical antipsychotic [PDF]
The treatment of psychiatric disorders is still an unresolved problem in our society and schizophrenia, the 12th cause of disability in the world, is an important and serious mental disorder.
Marinho, Elina Margarida Ribeiro
core +1 more source
Ligand-Controlled Chemoselective One-Pot Synthesis of Dibenzothiazepinones and Dibenzoxazepinones via Twice Copper-Catalyzed Cross-Coupling [PDF]
, 2017 A highly efficient and generally applicable protocol, starting from 2-bromobenzamides and 2-bromo(thio)phenols via twice copper-catalyzed couplings to afford dibenzothiazepines and dibenzoxazepinones has been developed.
Jian Hu +6 more
core +1 more source
Heterocyclic Communications, 2018 Abstract Dibenzothiazepine analogues containing lactam, amidine and imine moieties were prepared from 2-aminophenyl disulfides via one-pot S -arylation. The S -arylation involved cleavage of an S-
Yasutaka Shimotori +5 more
openaire +1 more source
, 1962 Some 3,6-diaryl-2,7-dihydrothiadiazepines are prepared and converted into 3,6-diarylpyridazines either thermally or by means of N-bromo succinimide in carbon tetrachloride.
Young, L. B
core
Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
, 2011 The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
core +1 more source