Results 11 to 20 of about 77,797 (232)

Phase I/II study of adding intraperitoneal paclitaxel in patients with pancreatic cancer and peritoneal metastasis

BJS (British Journal of Surgery), Volume 107, Issue 13, Page 1811-1817, December 2020., 2020
This multicentre phase I/II study was undertaken to determine the recommended dose of the combination of intravenous gemcitabine, intravenous nab‐paclitaxel and intraperitoneal paclitaxel in patients with pancreatic ductal adenocarcinoma and peritoneal metastasis, and to evaluate its clinical efficacy and safety.
S. Yamada, T. Fujii, T. Yamamoto, H. Takami, I. Yoshioka, S. Yamaki, F. Sonohara, K. Shibuya, F. Motoi, S. Hirano, Y. Murakami, H. Inoue, M. Hayashi, K. Murotani, J. Kitayama, H. Ishikawa, Y. Kodera, M. Sekimoto, S. Satoi   +18 more
wiley   +1 more source

Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin

BJS (British Journal of Surgery), Volume 107, Issue 13, Page 1801-1810, December 2020., 2020
In UK practice, surgical resection margin status is often used to stratify patients for receipt of adjuvant treatment. This cohort study suggested both an overall and recurrence‐free survival benefit following adjuvant therapy in patients with positive margins, who had undergone neoadjuvant chemotherapy and resectional surgery for oesophageal ...
R. K. Bott, K. Beckmann, J. Zylstra, M. J. Wilkinson, W. R. C. Knight, C. R. Baker, M. Kelly, N. Maisey, A. Qureshi, T. Sevitt, M. Van Hemelrijck, E. C. Smyth, W. H. Allum, J. Lagergren, J. A. Gossage, D. Cunningham, A. R. Davies, Guy's and St Thomas' Oesophagogastric Research Group, R. McEwan, A. Jacques, N. Griffin, V. Goh, S. Ngan, K. Owczarczyk, H. Deere, M. Green, F. Chang, U. Mahadeva, B. Gill‐Barman, S. George, J. Meenan, M. Hill, J. Waters, M. Cominos, O. Hynes, A. Coombes, G. Tham, C. Iezzi, A. Reyhani, J. M. Dunn, S. S. Zeki   +40 more
wiley   +1 more source

Comparison of the Peritoneal Cancer Index and Dutch region count as tools to stage patients with peritoneal metastases of colorectal cancer

BJS Open, Volume 4, Issue 6, Page 1153-1161, December 2020., 2020
This retrospective study compared two classification tools, the Dutch region count and the Peritoneal Cancer Index, for colorectal peritoneal metastases, and validated the results in a separate cohort. The region count was easier to apply, and may benefit doctors who refer patients to expert centres.
F. S. Verheij, C. Bakkers, W. J. van Eden, A. G. J. Aalbers, S. W. Nienhuijs, K. Jóźwiak, I. H. J. T. de Hingh, N. F. M. Kok   +7 more
wiley   +1 more source

Tumour growth rate of carcinoma of the colon and rectum: retrospective cohort study

BJS Open, Volume 4, Issue 6, Page 1200-1207, December 2020., 2020
Few studies have evaluated the growth pattern of colorectal cancer. Forty‐three patients who underwent CT twice more than 5 weeks apart were included over a 2‐year interval. The median doubling time was 211 days, with a concerning suggestion of tumour progression.
J. R. Burke, P. Brown, A. Quyn, H. Lambie, D. Tolan, P. Sagar   +5 more
wiley   +1 more source

Impact of extent of disease on 1‐year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study

BJS Open, Volume 4, Issue 5, Page 954-962, October 2020., 2020
Well selected patients with colorectal peritoneal metastases can be treated with curative intent by cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Treatment‐related healthcare costs are significantly increased among patients with extensive peritoneal disease, although the associated survival gain is limited.
B. J. L. Kooijman, J. E. K. R. Hentzen, C. S. van der Hilst, L. B. Been, R. J. van Ginkel, P. H. J. Hemmer, J. M. Klaase, S. Kruijff   +7 more
wiley   +1 more source

Impact on postoperative complications of changes in skeletal muscle mass during neoadjuvant chemotherapy for gastro‐oesophageal cancer

BJS Open, Volume 4, Issue 5, Page 847-854, October 2020., 2020
Deconditioning during neoadjuvant chemotherapy is a possible parameter for predicting operative outcomes. This retrospective cohort study aimed to assess body composition changes in patients with gastro‐oesophageal cancer during neoadjuvant therapy and investigate their association with postoperative complications. Skeletal muscle index values decrease
R. B. den Boer, K. I. Jones, S. Ash, G. I. van Boxel, R. S. Gillies, T. O'Donnell, J. P. Ruurda, B. Sgromo, M. A. Silva, N. D. Maynard   +9 more
wiley   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]

, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo, Afonine, Amundsen, Amundsen, Bannister, Baños-Sanz, Cano, Cirz, CLSI, Cole, Court, Court, Cronan, Darrigo, Datta, Dillingham, Emsley, Forage, González-Soltero, Henderson, Kennaway, Kulkarni, Li, Liu, Liu, López, McDaniel, Murphy, Murphy, Murphy, Muyrers, Paczosa, Pettersen, Robinson, Sakaki, Scheres, Singleton, Tamae, Urnavicius, Wang, Wiegand, Wigley, Wilkinson, Zhang, Zhang   +44 more
core   +5 more sources

Effects of high‐intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro‐oesophageal junction: PRESET pilot study

BJS Open, Volume 4, Issue 5, Page 855-864, October 2020., 2020
With concurrent aerobic exercise and resistance training twice a week during treatment, patients with cancer of the gastro‐oesophageal junction can return cardiopulmonary fitness and muscle strength to pretreatment levels at completion of treatment.
C. Simonsen, S. Thorsen‐Streit, A. Sundberg, S. S. Djurhuus, C. E. Mortensen, C. Qvortrup, B. K. Pedersen, L. B. Svendsen, P. de Heer, J. F. Christensen   +9 more
wiley   +1 more source

Chemobrain: revisión de estudios que evalúan el deterioro cognitivo de supervivientes de cáncer tratados con quimioterapia [PDF]

, 2012
The problem: Some cancer patients have expressed attention, concentration and memory problems, during and after their treatment with chemotherapy, also called chemobrain. Following these complains, in recent decades, studies about this adverse effect had
Cruzado, Juan A., Feliú, Jaime, López-Santiago, Sonia   +2 more
core   +8 more sources

Factors associated with sleep quality during chemotherapy: An integrative review

Nursing Open, Volume 7, Issue 5, Page 1274-1284, September 2020., 2020
Abstract Aim To identify the most important factors associated with sleep pattern changes in patients with cancer during chemotherapy treatment. Design An integrative review of the literature was performed between December 2017–August 2018. Methods Two independent reviewers searching the National Library of Medicine (PubMed/MEDLINE), Cumulative Index ...
Regina Claudia da Silva Souza, Maiara Rodrigues dos Santos, Izabel Alves das Chagas Valota, Cristina Silva Sousa, Ana Lucia Siqueira Costa Calache   +4 more
wiley   +1 more source