Results 31 to 40 of about 11,113 (225)

Repurposing of Anti-Malarial Drug Quinacrine for Cancer Treatment: A Review

Scientia Pharmaceutica, 2022
Quinacrine (QC), a synthetic drug belonging to the 9-aminoacridine family, has been used extensively to treat malaria and multiple ailments over the past several decades. Following its discovery in the 1920s and extensive use for the treatment of malaria
Makhan Kumar, Angshuman Sarkar
doaj   +1 more source

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes [PDF]

, 1984
Two cloned repetitive DNA probes, pXBR and CY1, which bind preferentially to specific regions of the human X and Y chromosome, respectively, were used to study the distribution of the sex chromosomes in human lymphocyte nuclei by in situ hybridization ...
C. R. M�ller, CR M�ller, DE Comings, F Pera, F Vogel, G. A. Rappold, GA Rappold, GA Rappold, H-D Hager, H. D. Hager, JR Gosden, K. E. Davies, L Avivi, L Hens, L Hens, LM Kunkel, M Schmid, M Spaeter, MD Bennett, ML Law, P Goodfellow, PL Pearson, PS Gerhard, R Gagn�, R Lewin, T Cremer, T Cremer, T Yang, T. Cremer, T. Yang, V Kanda   +30 more
core   +1 more source

Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro

Viruses, 2021
Quinacrine (Qx), a molecule used as an antimalarial, has shown anticancer, antiprion, and antiviral activity. The most relevant antiviral activities of Qx are related to its ability to raise pH in acidic organelles, diminishing viral enzymatic activity ...
Mónica Salas Rojas, Raúl Silva Garcia, Estela Bini, Verónica Pérez de la Cruz, Juan Carlos León Contreras, Rogelio Hernández Pando, Fernando Bastida Gonzalez, Eduardo Davila-Gonzalez, Mario Orozco Morales, Armando Gamboa Domínguez, Julio Sotelo, Benjamín Pineda   +11 more
doaj   +1 more source

Pharmacokinetics of quinacrine in the treatment of prion disease

BMC Infectious Diseases, 2004
Background Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrPSc. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) to PrPSc at a half-maximal ...
Baldwin Michael, Lin Emil T, Legname Giuseppe, Lessard Pierre, Huang Yong, Yung Lotus, Prusiner Stanley B, Ryou Chongsuk, Guglielmo B Joseph   +8 more
doaj   +1 more source

Effects of Autophagy Inhibition by SAR405, a Selective VPS34 Inhibitor, on Pleural Mesothelioma Cells. [PDF]

Thorac Cancer
SAR405, a selective VPS34 inhibitor, suppressed autophagic flux and reduced cell viability, colony formation, and invasion in pleural mesothelioma cell lines. SAR405 induced apoptosis only in H2452 cells. Cisplatin weakly induced autophagy, but its combination with SAR405 showed no synergistic cytotoxic effects. ABSTRACT Background Pleural mesothelioma
Kuwabara Y, Sakai K, Shiraishi K, Matsumoto I, Ishii S, Yokosuka S, Abe M, Takahashi T, Kawano Y, Nishimura H, Toda-Sasaki M, Kobayashi-Ogawa Y, Kikuchi S, Hirata Y, Kyoyama H, Moriyama G, Koyama N, Uematsu K.   +17 more
europepmc   +2 more sources

Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)

Journal of Biological Research, 2011
The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrPSc-like structure affecting the survival of SH-SY5Y cells.
V. Villa, A. Corsaro, S. Thellung, A. Simi, M. Nizzari, M. Tonelli, V. Boido, A. Aceto, T. Florio   +8 more
doaj   +1 more source

Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments [PDF]

, 1982
Unsynchronized cells of an essentially diploid strain of female Chinese hamster cells derived from lung tissue (CHL) were laser-UV-microirradiated (=257 nm) in the nucleus either at its central part or at its periphery.
B Dutrillaux, BA Kihlman, C Cremer, C Cremer, C Cremer, C Cremer, C Wollenberg, C Zorn, C Zorn, C. Cremer, DE Barton, DE Comings, DE Comings, E Therman, F Vogel, FE Fosse Del, H Kato, H. Baumann, HD Hager, JW Gray, K Church, K Nilsson, L Avivi, L Hens, L Hens, L. Hens, LL Deaven, M Ray, M Schmid, M. Kirsch-Volders, S Brenner, T Caspersson, T Cremer, T Cremer, T. Cremer, T. Schneider, Th Boveri, W Sauerbier, Y Moroi   +38 more
core   +1 more source

Diffusion of small molecule drugs is affected by surface interactions and crowder proteins

iScience, 2022
Summary: Crowded environments are known to affect the diffusion of macromolecules, but their effects on the diffusion of small molecules are largely uncharacterized.
Debabrata Dey, Ariane Nunes-Alves, Rebecca C. Wade, Gideon Schreiber   +3 more
doaj   +1 more source

Predictors of Failure from Primary Therapy for Giardiasis in San Diego: A Single Institution Retrospective Review. [PDF]

, 2019
This study aimed to determine the presence of giardiasis among HIV patients in San Diego, the rate of failure of metronidazole treatment, and factors associated with treatment failure.
Debnath, Anjan, Morris, Sheldon R, Reed, Sharon L   +2 more
core   +1 more source

Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation in Gorilla gorilla [PDF]

, 1992
The existence of an apomorphic reciprocal chromosomal translocation in the gorilla lineage has been asserted or denied by various cytogeneticists. We employed a new molecular cytogenetic strategy (chromosomal in situ suppression hybridization) combined ...
Bigoni, F., Cremer, Thomas, Jauch, Anna, Romagno, D., Stanyon, Roscoe, Wienberg, Johannes   +5 more
core   +1 more source