Results 41 to 50 of about 11,113 (225)

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines using ristocetin macrocyclic glycopeptide antibiotics CSP

Journal of Taibah University for Science, 2020
The enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines is described on Chirobiotc R column (150 ×4.6 mm, 5.0 µm). Two eluents used were methanol–acetonitrile-water-triethyl amine in the ratio of 70:10:20:0.1 (I) and
Zeid A. ALOthman, Abdullah G. ALanazi, Imran Ali   +2 more
doaj   +1 more source

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

Nature Communications, 2021
Chemoresistance and relapse are main limitations in the treatment of acute lymphoblastic leukemia (ALL). Here, the authors identify Quinacrine (QC) as a sensitizer for Cytarabine (AraC) and establish a QC-CASIN regimen to improve leukemia eradication in ...
Limei Wu, Srinivas Chatla, Qiqi Lin, Fabliha Ahmed Chowdhury, Werner Geldenhuys, Wei Du   +5 more
doaj   +1 more source

Viability of Giardia intestinalis cysts : assessing viability under environmental conditions : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand [PDF]

, 1998
Much work has been put into the detection and monitoring of Giardia, but once found, it is not easy to tell whether the cysts are viable and thus infective.
Kakubayashi, Michiko
core  

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Effect of p53 activation on experimental right ventricular hypertrophy.

PLoS ONE, 2020
The leading cause of death in Pulmonary Arterial Hypertension (PAH) is right ventricular (RV) failure. The tumor suppressor p53 has been associated with left ventricular hypertrophy (LVH) and remodeling but its role in RV hypertrophy (RVH) is unclear ...
Swathi Veeroju, Argen Mamazhakypov, Nabham Rai, Baktybek Kojonazarov, Valerie Nadeau, Sandra Breuils-Bonnet, Ling Li, Norbert Weissmann, Susanne Rohrbach, Steve Provencher, Sébastien Bonnet, Werner Seeger, Ralph Schermuly, Tatyana Novoyatleva   +13 more
doaj   +1 more source

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, EarlyView.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A [PDF]

, 2009
Background It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear.
Ji-Fu Wei, Xiao-Long Wei, Ya-Zhen Mo, Shao-Heng He   +3 more
core   +2 more sources

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

Frontiers in Chemistry
ObjectiveThis study aims to investigate the toxicity characteristics and mechanisms of quinacrine acetate, a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, and to establish and validate the application value of network toxicology ...
Jinchao Zhu, Qingyuan Lin, Honglin Zhu, Siqi Xie, Shengdong Nie   +4 more
doaj   +1 more source

Kaelin Rapport - Histological Techniques for the Sex Determination of Skeletonized Human Remains [PDF]

, 2014
Determining the sex of skeletons is problematic in forensic and bio-archaeological research. Past studies demonstrate that bone cells can sometimes contain preserved sex chromosomal material in ancient samples. The sex chromosomes in skeletal remains may
Rapport, Kaelin
core   +1 more source