Results 21 to 30 of about 11,113 (225)

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, Collinge, J, Lowe, J, Lukic, A, MacKay, A, Mead, S, Porter, MC, Rudge, P, Thompson, AG, Uphill, J   +9 more
core   +1 more source

Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression

Scientific Reports, 2021
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, seen ...
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G. Dawson, David A. Moore, David A. Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C. Boutros, Shu-Dong Zhang, Dean A. Fennell   +17 more
doaj   +1 more source

Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis

Translational Oncology, 2022
Malignant melanoma is a highly aggressive, malignant, and drug-resistant tumor. It lacks an efficient treatment approach. In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine,
Xuan Zheng, Jianyun Zhang, Shuangting Li, Xiaolei Gao, Yixin Zhang, Meng Wang, Liying Dong, Liangjie Sun, Na Zhao, Zeyun Ma, Chong Ding, Yixiang Wang   +11 more
doaj   +1 more source

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation.

PLoS ONE, 2014
We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine.
Merryl R Lobo, Xiaoyan Wang, G Yancey Gillespie, Randall L Woltjer, Martin M Pike   +4 more
doaj   +1 more source

Candidate drug replacements for quinacrine in cutaneous lupus erythematosus

Lupus Science and Medicine, 2020
Cutaneous lupus erythematosus (CLE) is a disfiguring and potentially disabling disease that causes significant morbidity in patients. Antimalarials are an important class of medication used to treat this disease and have been the first-line systemic ...
Victoria P Werth, Robert Borucki, Richard D Sontheimer   +2 more
doaj   +1 more source

A case of hyperpigmentation induced by hydroxychloroquine and quinacrine in a patient with systemic lupus erythematosus and review of the literature

International Journal of Women's Dermatology, 2020
Hydroxychloroquine (HQ) and quinacrine are widely used antimalarials for systemic lupus erythematosus (SLE) and other autoimmune diseases. We report a case of antimalarial-induced hyperpigmentation in a 57-year old African-American woman. The patient had
Daniel Kwak, Pearl E. Grimes, MD
doaj   +1 more source

Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments

Molecules, 2021
Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease.
Mélanie Fonte, Natália Tassi, Paula Gomes, Cátia Teixeira   +3 more
doaj   +1 more source

Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]

, 2008
The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Cecchi, Marie, Guiresse, Agnès Maritchù, Perchet, Geoffrey-Thibault, Pinelli, Eric, Pourrut, Bertrand, Silvestre, Jérôme   +5 more
core   +3 more sources

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources