Repositioning Quinacrine Toward Treatment of Ovarian Cancer by Rational Combination With TRAIL
Frontiers in Oncology, 2020 Quinacrine has been identified as a potent DR5-inducing agent that sensitizes cancer cells to TRAIL-induced apoptosis. In the current study, we found that quinacrine increased DR5 mRNA levels significantly in ovarian cancer cell lines regardless of p53 ...
Yanqiao Zhang +2 more
exaly +3 more sources
SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma [PDF]
Advanced SciencePeripheral T‐cell lymphoma (PTCL) is a heterogeneous group of mature T‐cell malignancies with poor prognosis. Therefore, improved therapies are urgently required to improve patient outcomes.
Yimin Ren +13 more
doaj +2 more sources
Essais de traitement de la péripneumonie contagieuse bovine par la mépacrine [PDF]
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1968 Bactériostatique in vitro vis-à-vis de M. mycoides à la quantité de 10 ug/ml, la Mépacrine (Quinacrine Spécia) n'arrête pourtant pas in vivo le déroulement du phénomène de Willems ni ne guérit, même cliniquement, la péripneumonie ...
Alain Provost, R. Quéval
doaj +3 more sources
Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter. [PDF]
PLoS ONE, 2012 The lipophilic cationic compound quinacrine has been used as an antimalarial drug for over 75 years but its pharmacokinetic profile is limited. Here, we report on the pharmacokinetic properties of quinacrine in mice.
Misol Ahn +7 more
doaj +1 more source
Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations
Frontiers in Pharmacology, 2021 Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors.
Derek B. Oien +5 more
doaj +1 more source
INRAE Productions Animales, 2020 En raison des incertitudes épidémiologiques relatives aux maladies à prions, il est urgent de découvrir et de développer des thérapeutiques anti-prions chez l’homme.
N. PICARD-HAGEN +4 more
doaj +1 more source
Quinacrine impairs enterovirus 71 RNA replication by preventing binding of polypyrimidine-tract binding protein with internal ribosome entry sites. [PDF]
PLoS ONE, 2013 Since the 1980s, epidemics of enterovirus 71 (EV71) and other enteroviruses have occurred in Asian countries and regions, causing a wide range of human diseases. No effective therapy is available for the treatment of these infections.
Jianmin Wang +3 more
doaj +1 more source
Pharmaceutics, 2020 Lysosomal trapping at the blood–retinal barrier (BRB) was investigated through quinacrine and fluorescence-labeled verapamil (EFV) uptake. Quinacrine uptake by conditionally immortalized rat retinal capillary endothelial (TR-iBRB2) cells suggested ...
Yoshiyuki Kubo +4 more
doaj +1 more source
Scientific Reports, 2021 Alzheimer’s disease (AD) is the most common type of dementia characterized by the abnormal accumulation of amyloid-β (Aβ) in the brain. Aβ misfolding is associated with neuroinflammation and synaptic dysfunction, leading to learning and memory deficits ...
Sohui Park +7 more
doaj +1 more source
Identification of a small molecule that modifies MglA/SspA interaction and impairs intramacrophage survival of Francisella tularensis. [PDF]
PLoS ONE, 2013 The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes.
Algevis P Wrench +3 more
doaj +1 more source